5-Nok (nitroxoline) coated tablets 50 mg. №50 vial


Manufacturer: Slovenia

Acute, chronic and recurrent urinary tract infections caused by gram-positive and gram-negative microorganisms and fungi sensitive to nitroxoline.
Prevention of recurrent urinary tract infections.
It is necessary to conduct a microbiological study to identify the infectious agent and check its sensitivity to nitroxoline before prescribing. However, if there is reason to believe that the infection is most likely caused by a micro-organism sensitive to 5-NOC, treatment may be started before the results of the study are obtained.

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5-Nok: antimicrobial derivative of 8-hydroxyquinoline.

It has a wide spectrum of action. Selectively inhibits the synthesis of bacterial DNA, forms complexes with metal-containing enzymes of the microbial cell.

Active against gram-positive bacteria:

  • Staphylococcus spp. (including Staphylococcus aureus),
  • Streptococcus spp. (including beta-hemolytic streptococci,
  • Streptococcus pneumoniae,
  • Enterococcus faecalis),
  • Corynebacterium spp.,
  • Bacillus subtilis;

Gram-negative bacteria:

  • Escherichia coli,
  • Proteus spp.,
  • Klebsiella spp.,
  • Salmonella spp.,
  • Shigella spp.,
  • Enterobacter spp.,
  • Haemophilus influenzae,
  • Neisseria gonorrhoeae;

Other microorganisms:

  • Ureaplasma urealyticum,
  • Mycoplasma hominis,
  • Mycobacterium tuberculosis,
  • Trichomonas vaginalis.

Effective against certain types of fungi (candida, dermatophytes, mold fungi, some pathogens of deep mycoses).

Indications for use of 5-Nok:
Treatment of acute, chronic and recurrent urinary tract infections caused by microorganisms sensitive to nitroxoline:

  • pyelonephritis;
  • cystitis;
  • urethritis;
  • epididymitis;
  • infected prostate adenoma or carcinoma.

Prevention of infectious complications in the postoperative period during surgical interventions on the kidneys and genitourinary tract, as well as during diagnostic and therapeutic procedures (catheterization, cystoscopy).

Prevention of recurrent urinary tract infections.