Admenta (Memantin) 10 coated tablets 10 mg. №30


Manufacturer: India

Memantine is a medication used to treat moderate to severe dementia in Alzheimer’s disease. It comes in the form of a coated tablet.




Memantine hydrochloride 10 mg

Excipients: microcrystalline cellulose – 152.5 mg, calcium hydrogen phosphate dihydrate – 50 mg, croscarmellose sodium – 12.5 mg, lactose monohydrate – 10 mg, hyprolose (hydroxypropylcellulose) – 5 mg, talc – 5 mg, colloidal silicon dioxide – 2.5 mg, magnesium stearate – 2.5 mg.

The composition of the film shell: (hypromellose – 4 mg, hyprolose (hydroxypropyl cellulose) – 1.552 mg, talc – 1.568 mg, titanium dioxide – 0.88 mg) or (dry mixture for film coating, hypromellose (50%), hyprolose (hydroxypropyl cellulose) (19.4% ), talc (19.6%), titanium dioxide (11%)) – 8 mg.

Pharmachologic effect of Memantine hydrochloride

A remedy for the treatment of dementia. It is a non-competitive antagonist of glutamate NMDA receptors (including in the substantia nigra), as a result, it reduces the excessive stimulating effect of cortical glutamate neurons on the neostriatum, which develops against the background of insufficient release of dopamine. By reducing the flow of Ca2+ into neurons, it reduces the possibility of their destruction. It has nootropic, cerebrovasodilating, antihypoxic and psychostimulating effects. Improves impaired memory, increases the ability to concentrate, reduces fatigue and symptoms of depression, reduces spasticity of skeletal muscles caused by diseases or brain damage.

Pharmacokinetics. After oral administration, it is rapidly and completely absorbed from the gastrointestinal tract. Cmax is reached in 3-8 hours. Plasma protein binding is 45%. When taken at a dose of 20 mg / day, a Css of 70 to 150 ng / ml is achieved. Vd is 10 l/kg. Partially metabolized in the liver. Excreted by the kidneys. T1 / 2 is – 60-100 hours; clearance is 170 ml / min / 1.73 m2.

Indication for use

Moderate to severe dementia in Alzheimer’s disease.

Dosage and administration

The method of application and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed. When taken orally, the initial dose for adults is 5 mg / day. In the future, the dose can be increased weekly by 5 mg. The average maintenance dose is 10-20 mg / day. The maximum dose is 20 mg / day.

Side effects

  • the nervous system: dizziness, headache, drowsiness, gait disturbance, confusion, hallucinations, convulsions, psychosis, irritability. From the digestive system: constipation, vomiting, nausea, pancreatitis.
  • the cardiovascular system: increased blood pressure, venous thrombosis, thromboembolism.
  • the body as a whole: fungal infections, general weakness, fatigue, allergic reactions.


  • severe liver failure;
  • pregnancy;
  • lactation period (breastfeeding);
  • children and adolescents under 18 years of age (the effectiveness and safety of the drug have not been studied);
  • hypersensitivity to memantine.

Special instructions

Should be used with caution for patients with epilepsy, renal failure, thyrotoxicosis, a history of convulsions, arterial hypertension, a history of myocardial infarction, heart failure.

In case of impaired renal function, the dose of memantine should be reduced.