Aesculus oral drops 20 ml. vial №1


Manufacturer: Ukraine

In the complex treatment of peripheral blood circulation disorders: diabetic angiopathy of the lower extremities of the II-i degree, varicose veins, including hemorrhoids, obliterating endarteritis of the lower extremities and their gangrenous state, post-stroke and post-infarction conditions, bedsores, discirculatory encephalopathy.



Aesculus Composition
active ingredients:

100 g of the preparation contain: horse chestnut seed extract standardized (Hippocastani seminis extractum siccum normatum) (5-7: 1) (extractant: ethanol 60% (v / v)) – 4.725 g, thiamine hydrochloride – 0.5 g;

Aesculus excipients: ethanol 96%; purified water lactose monohydrate, colloidal silicon dioxide.

Dosage form
Oral drops, solution.

Basic physical and chemical properties: clear or slightly turbid liquid from yellow to reddish brown with a characteristic odor. During storage, sediment may form.

Pharmacotherapeutic group
Capillary stabilizing agents. ATX code С05С Х.

Angioprotective, capillary stabilizing, decongestant, anti-inflammatory agent. The mechanism of action of escin is due to the stabilization of lysosomal membranes, inhibition of the release of autolytic cellular enzymes, as a result of which the disintegration of mucopolysaccharides decreases and trophic processes in the walls of venous vessels and the surrounding connective tissue improve. The drug reduces pathologically increased vascular tissue permeability, preventing transcapillary filtration of low molecular weight proteins, electrolytes and water into the intercellular space, increases the tone of the venous wall, eliminates venous congestion (especially in the lower extremities), reduces peripheral edema, reduces the feeling of heaviness in the legs, fatigue, tension , itching, pain.

When taken orally, escin is rapidly absorbed, mainly from the duodenum. Subject to the pronounced effect of the first passage through the liver. In interstitial fluid and blood plasma, escin binds to proteins (approximately 84%) and cholesterol. Metabolized in the liver. It is excreted from the body in the urine and bile in the form of metabolites.

Thiamine hydrochloride in the body is converted into active thiamine diphosphate, is involved in carbohydrate and energy metabolism, is a coenzyme of many enzymatic reactions.

Aesculus Indications
Chronic venous insufficiency:
cramps of the calf muscles;
itching, as well as pain and a feeling of heaviness in the legs;
Post-thrombotic syndrome.
Trophic changes in the veins of the lower extremities, for example, leg ulcers.
Prevention and treatment of post-traumatic and postoperative edema and hematomas.
Hypersensitivity to the components of the drug. Renal failure, allergic diseases.