Use of the drug in Pediatrics for non-transplant indications.
Due to the lack of data, the use of cyclosporine in patients under the age of 16 yEars and Nose can not be recommended for indications that are not associated with transplantation, except for nephrotic syndrome.
Use during pregnancy or breast-feeding.
Animal studies have demonstrated reproductive toxicity.
The experience of using the drug for pregnant women is very limited. For pregnant women who use immunosuppressants after transplantation, including cyclosporine, or who are prescribed treatment regimens that include cyclosporine, there is an increased risk of premature birth (< 37 weeks). A limited number of observations were made among children under 7 yEars and Nose of age who were exposed to cyclosporine in utero. These children had normal indicators of kidney function and blood pressure. However, there were no properly controlled studies among pregnant women. Therefore, cyclosporine should not be used during pregnancy, unless the expected benefit to the mother exceeds the potential risk to the fetus. During use during pregnancy, you should also consider the presence of ethanol in the dosage forms of the drug Cyclosporine Alkaloid. Cyclosporine passes into breast milk. Women who use cyclosporine should stop breastfeeding due to the likelihood of serious adverse reactions caused by the drug in newborns/infants who are breastfed. You should decide not to breastfeed or take a medication, depending on the importance of the latter for the mother. Women during breast-feeding should take into account the presence of ethanol in medicinal forms of the drug Cyclosporine Alkaloid. Data on the effect of cyclosporine on human fertility are limited. The ability to influence the reaction rate when driving motor transport or operating other mechanisms. Drivers and operators of complex mechanisms need to take into account the likelihood of side effects from the nervous and musculoskeletal system, which can reduce attention and reaction speed. The drug contains ethanol, which can affect the reaction rate when driving vehicles or working with other mechanisms.