Essential hypertension (both mono-and combined therapy). Chronic stable angina. Moderate to severe chronic heart failure as an additional therapy. Contraindications. Hypersensitivity to the active substance or to any of the excipients of the drug decompensated heart failure – class IV heart failure according to the NYHA classification, which requires the introduction of inotropic agents; grade II and i blockage (except when a permanent pacemaker is installed) concomitant administration of verapamil, diltiazem, or other antiarrhythmic agents (especially class I antiarrhythmic agents) severe bradycardia (heart rate <50 beats / min) severe hypotension (systolic pressure below 85 mmHg). st.) cardiogenic shock sinus node weakness syndrome (including sinoatrial block) uncompensated heart failure requiring the administration of positive isotropic and / or diuretics; pulmonary heart, pulmonary hypertension bronchial asthma or obstructive diseases of the respiratory tract, accompanied by bronchospasm; pheochromocytoma (except when it is properly controlled when using alpha blockers) prinzmetal; severe liver function disorders; simultaneous use of MAO inhibitors (with the exception of MAO-B inhibitors); galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption; metabolic acidosis, pregnancy and lactation, children's age.