Duak (benzoyl anhydrous peroxide) gel 15 g.


Manufacturer: Netherlands

Local treatment of acne (acne vulgaris) of mild to moderate severity, mainly inflammatory elements, in adults and children older than 12 yEars and Nose.



Duak Composition
active ingredients: anhydrous benzoyl peroxide (in the form of water benzoyl peroxide), clindamycin (in the form of clindamycin phosphate);

1 g of gel contains anhydrous benzoyl peroxide (in the form of water benzoyl peroxide) 50 mg of clindamycin (in the form of clindamycin phosphate) 10 mg;

Duak excipients: carbomer, dimethicone, sodium lauryl sulfosuccinate, Trilon B, glycerin, water silicon dioxide, poloxamer, sodium hydroxide, purified water.

Duak Dosage form

Basic physical and chemical properties: homogeneous white or slightly yellowish gel.

Pharmacotherapeutic group
Local remedies for acne. ATX code D10A F51.

Clindamycin is a lincosamide antibiotic with bacteriostatic action against gram-positive aerobic microorganisms and a broad spectrum of anaerobic bacteria. Lincosamides such as clindamycin bind to the 23S subunit of the bacterial ribosome and inhibit the early stages of protein synthesis. The action of clindamycin is predominantly bacteriostatic, although high concentrations may have a slow bactericidal effect against susceptible strains.

Although clindamycin phosphate is inactive in vitro, rapid hydrolysis in vivo converts this compound against clindamycin bacteria. The antibacterial activity of clindamycin has been demonstrated clinically in the treatment of comedones in acne patients at levels sufficient to be active against most strains of Propionibacteium acnes. Clindamycin in vivo inhibits all tested cultures of Propionibacteium acnes (MIC-0.4 μg / ml). After the application of clindamycin, the percentage of free fatty acids on the skin surface decreased from about 14% to 2%.

Benzoyl peroxide has a mild keratolytic effect on comedones at all stages of their development. It is an oxidizing agent with bactericidal activity against Propionibacteium acnes, a microorganism that causes the development of acne vulgaris. In addition, it is a sebostatic agent that counteracts the excess production of sebum associated with acne.

The addition of benzoyl peroxide reduces the potential for clindamycin-resistant microorganisms.

Percutaneous absorption of clindamycin is minimal. The presence of benzoyl peroxide in the drug did not affect the percutaneous absorption of clindamycin. Radiolabeling studies have shown that absorption of benzoyl peroxide through the skin is only possible after it has been converted to benzoic acid. Benzoic acid is predominantly conjugated to form hippuric acid, which is excreted by the kidneys.

Local treatment of acne (acne vulgaris) of mild to moderate severity, mainly inflammatory elements, in adults and children over 12 years old.

Hypersensitivity to the components of the drug and lincomycin. Local enteritis, ulcerative colitis, or antibiotic-associated colitis (including pseudomembranous colitis) or a history of them. Age up to 12 years.