DUOPAK is a source of lactobacilli, bifidobacteria, prebiotics and vitamins. The synergistic combination of components helps restore and normalize the microflora intestinal dysbiotic disorders, after the use of antibiotics and chemotherapy by: – acute intestinal infections (salmonellosis, schelesny infection esherihioz, viral intestinal infection).  when intestinal infection normoflora, as a rule, sharply suppressed, and the need for antibacterial therapy leads to even more inhibition of lacto-and bifidobacteria. Therefore, in the process of reconvalescence after intestinal infections usually require normalization of the intestinal microflora; – inflammatory diseases of the respiratory, digestive, urogenital system, musculoskeletal system apparatus, purulent-inflammatory diseases, including prevention of development antibiotic-associated diarrhea and pseudomembranous colitis. It is known that the antibiotic- associated diarrhea develops in 5-30% of cases of antibiotic use (depending on depending on the type and duration of its course). Violation of intestinal microflora, clinically they are manifested, but are diagnosed by microbiological methods, and are noted in more than 70% of cases the use of modern antibiotics [1, 2]. In this case, as a rule, the doctor it is not always possible to determine the lack of specific representatives of the normoflora. The presence of representatives of both lacto-and bifidobacteria in the composition of DUOPIC allows use it in all cases where normalization of the intestinal composition is necessary microfloras; – chronic inflammatory and dyskinetic diseases of the gastrointestinal tract and the digestive system . Violation of the composition of the intestinal microflora is frequent a symptom of these diseases, as well as one of the links of their pathogenesis, since conditionally pathogenic microflora can support chronic inflammatory process in the stomach- intestinal tract. Sub-products of life activity of conditionally pathogenic microflora provide endogenous intoxication syndrome in these diseases; – allergic diseases and conditions (atopic dermatitis, neurodermatitis, urticaria, bronchial asthma, etc.). [5, 6] intestinal normoflora is an important natural immunomodulating mechanism, while opportunistic microorganisms are capable of produce substances that support an allergic reaction. For example, in the process microbial decarboxylation of the amino acid histidine forms an Allergy mediator – histamine. This process is sharply inhibited by a decrease in the pH of the intestinal contents, which provided by bifidobacteria; – diseases of the endocrine system (diabetes mellitus) . Metabolic disorders in this disease creates prerequisites for the development of opportunistic microflora: violation of carbohydrate metabolism next to the suppression of the immune system makes it possible to actively to develop, for example, the fungi of R. Sagitta. Therefore, measures to maintain the normal flora is an important component of improving the quality of life of patients.