Adults and children aged 10 and over: symptomatic treatment of abdominal pain and spasms, bowel disorders and discomfort in the bowel area in irritable bowel syndrome; the treatment of gastrointestinal spasm secondary origin, caused by organic disease.
active substance: mebeverine hydrochloride;
1 tablet contains 135 mg of mebeverine hydrochloride;
Duspatalin excipients: lactose monohydrate, potato starch; povidone, talc magnesium stearate;
shell: talc, sucrose, gelatin, acacia, carnauba wax.
Duspatalin Dosage form
Basic physical and chemical properties: a white, round, sugar-coated tablet with a diameter of about 11 mm and a weight of about 420 mg.
Remedies for functional gastrointestinal disorders. Synthetic anticholinergics, esterified tertiary amines. ATX code A03A A04.
Mebeverin is a myotropic antispasmodic with a direct effect on the smooth muscles of the gastrointestinal tract. It eliminates spasms without inhibiting normal intestinal motility.
Mebeverine is rapidly and completely absorbed by oral administration of tablets.
After repeated use, no significant accumulation is observed.
Meverine hydrochloride is mainly metabolized by esterases, which, at the first stage of metabolism, cleave ester bonds to form veratric acid and mebeverine alcohol.
In plasma, demethylcarboxylic acid (DMCA) is the main metabolite. The half-life of DMCC in equilibrium is 2.45 hours. With repeated use, Cmax and tmax of DMKK are 1670 ng / ml and 1 hour, respectively.
Mebeverine is completely metabolized and is not excreted unchanged, and metabolites are excreted almost completely. Veratric acid is excreted in the urine. Mebeverine alcohol is also excreted by the kidneys, partly as the corresponding carboxylic acid (CA) and partly as demethylcarboxylic acid (DMCA).
Symptomatic relief of irritable bowel syndrome.
Hypersensitivity to the active substance or to any excipient specified in the “Composition” section.
Interaction with other medicinal products and other forms of interaction
Interaction studies were not conducted, except for interactions with alcohol. In vitro and in vivo studies in animals have shown the absence of any interaction between mebeverine hydrochloride and ethanol.