Eczolik (naftifine hydrochloride) solution for external use 1% 10 ml. vial №1


Manufacturer: Japan

Local treatment of fungal infections caused by naftifin-sensitive pathogens: fungal infections of the skin and skin folds; interdigital mycoses; fungal infections of the nails; skin candidiasis; pityriasis versicolor; inflammatory dermatomycosis that may be accompanied by itching.



Eczolik Composition:

active substance: naftifine hydrochloride; 1 ml of solution contains: naftifine hydrochloride 10 mg or 20 ml; excipients: propylene glycol, ethanol 96%, purified water.

Eczolik Dosage form.

Cutaneous solution.

Eczolik Basic physical and chemical properties:

transparent, colorless to light yellow with a specific odor.

Pharmacotherapeutic group. Antifungal agents for dermatological use. ATX code D01A E22.

Eczolik Pharmacological properties.
Pharmacodynamics. Exolik is an antifungal agent of the allylamine class. Its active component is naftifine hydrochloride, the mechanism of action of which is associated with inhibition of the action of ergosterol.
Naftifine is active against dermatophytes such as trichophyton, epidermophyton and microsporum, yeast (Candida), mold (Aspergillus) and other fungi (for example, Sporothrix schenckii). On dermatophytes and aspergils, naftifine in vitro has a fungicidal effect, relative to yeast fungi – it exhibits fungicidal or fungistatic activity, depending on the strain of the microorganism.
Exolic also exhibits antibacterial activity against gram-positive and gram-negative microorganisms, which can cause secondary bacterial infection along with mycotic lesions.
In addition, Exolic has powerful anti-inflammatory properties.
Pharmacokinetics. Naftifine hydrochloride is rapidly absorbed and forms persistent antifungal concentrations in different layers of the skin. Approximately 4% of the dose applied to the skin is absorbed, therefore the systemic effect of the active substance is very low. Only trace amounts of naftifine are detected in blood plasma and urine. The active substance is almost completely metabolized; metabolites have no antifungal activity and are excreted in feces and urine. The half-life is 2-4 days.

Clinical characteristics.
Indications. Local treatment of fungal infections caused by pathogens sensitive to naftifine:
– fungal infections of the skin and skin folds;
– interdigital mycoses;
– fungal infections of the nails;
– cutaneous candidiasis;
– pityriasis versicolor;
– inflammatory dermatomycosis, which may be accompanied by itching.


Hypersensitivity to naftifine, propylene glycol or other components of the drug. The drug should not be applied to the wound surface. Do not use to treat eyes.

Interaction with other medicinal products and other types of interactions. Interaction studies have not been performed.

Features of the application.

The drug should be used for diseases of nails and skin only externally! The drug contains ethanol, therefore contact with the eyes and open wounds should be avoided. The solution contains propylene glycol, which may irritate the skin.

Application during pregnancy or lactation. There are no or limited data on the use of naftifine in pregnant women. The results of animal studies do not indicate the existence of a direct or indirect harmful effect of the drug on reproductive function. The drug can be used during pregnancy or lactation only if absolutely necessary after a careful assessment of the benefit / risk ratio, which is determined by the doctor.

The ability to influence the speed of reaction when driving vehicles or other mechanisms. Does not affect.

Method of administration and dosage.

Exolik solution should be applied to the affected skin surface and adjacent areas once a day after thorough cleansing and drying, covering approximately 1 cm of healthy skin along the edges of the affected area. Duration of treatment: for dermatomycosis – 2-4 weeks (if necessary – up to 8 weeks); with candidiasis – 4 weeks; for nail infections – up to 6 months.
In case of fungal diseases of the nails, the drug is recommended to be used 2 times a day. Before the first use, it is necessary to remove the affected area of ​​the nail as much as possible with scissors or a nail file (to facilitate this procedure, on the recommendation of a doctor, nails can be treated with a special softening agent).
To prevent relapses, treatment with the drug should be continued for at least 2 weeks after the main symptoms of the disease disappear.

Children.There is not enough data on the efficacy and safety of the drug for children, therefore it is not recommended to prescribe Exolik to patients of this age category.

Overdose. Acute overdose with topical application of naftifine was not observed. Systemic intoxication with external use of the drug is unlikely due to the fact that a small amount of the active substance is absorbed through the skin. In case of accidental ingestion of the drug, symptomatic treatment should be initiated.

Shelf life.

2 years.

Storage conditions.

Keep out of the reach of children. Store in its original packaging at a temperature not exceeding 25 ° C. After opening the bottle, store the solution for 6 months at a temperature not exceeding 25 ° C. Do not use after the expiration date.


10 ml in vials No. 1 in a pack. 20 ml in vials No. 1 in a pack.

Release category.

Over the counter.