Chronic venous insufficiency: oedemata; cramps of the calf muscles; itching, as well as pain and a feeling of heaviness in the legs; varicose veins. Post-thrombotic syndrome. Trophic changes in the veins of the lower extremities, for example, ulcers of the lower leg. Hemorrhoids. Prevention and treatment of post-traumatic and post-operative edema and hematomas.