Chronic venous insufficiency: oedemata; cramps of the calf muscles; itching, as well as pain and a feeling of heaviness in the legs; varicose veins. Post-thrombotic syndrome. Trophic changes in the veins of the lower extremities, for example, ulcers of the lower leg. Hemorrhoids. Prevention and treatment of post-traumatic and post-operative edema and hematomas.
active ingredients: 1 ml of the drug contains horse chestnut extract liquid (1: 7.1) (extractum semen hippocastani fluidum) (extractant ethanol 50%) – 90 mg in terms of 9 mg escin, thiamine hydrochloride – 4.5 mg;
excipients: ethanol 96%, purified water.
Escuvit Dosage form
Basic physical and chemical properties: liquid from yellow-brown to red-brown color. During storage, the formation of a slight sediment is allowed.
Capillary stabilizing agents. ATX code С05С X.
Angioprotective, capillary stabilizing, decongestant, anti-inflammatory agent. The mechanism of action of escin is due to the stabilization of lysosomal membranes, inhibition of the release of autolytic cellular enzymes, as a result of which the disintegration of mucopolysaccharides decreases and trophic processes in the walls of venous vessels and the surrounding connective tissue improve. The drug reduces pathologically increased vascular tissue permeability, preventing transcapillary filtration of low molecular weight proteins, electrolytes and water into the intercellular space, increases the tone of the venous wall, eliminates venous congestion (especially in the lower extremities), reduces peripheral edema, reduces the feeling of heaviness in the legs, fatigue, tension , itching, pain.
When taken orally, escin is rapidly absorbed, mainly from the duodenum. Subject to a pronounced “first pass” effect through the liver. In interstitial fluid and blood plasma, escin binds to proteins (approximately 84%) and cholesterol. Metabolized in the liver. It is excreted from the body in the urine and bile in the form of metabolites.
Thiamine hydrochloride in the body is converted into active thiamine diphosphate, is involved in carbohydrate and energy metabolism, is a coenzyme of many enzymatic reactions.
Chronic venous insufficiency:
cramps of the calf muscles;
itching, as well as pain and a feeling of heaviness in the legs;
Trophic changes in the veins of the lower extremities, for example, leg ulcers.
Prevention and treatment of post-traumatic and postoperative edema and hematomas.
Hypersensitivity to the components of the drug. Renal failure, allergic diseases.
Interaction with other medicinal products and other types of interactions
The drug can enhance the effect of antithrombotic agents. Cephalosporin antibiotics increase the concentration of free escin in the blood and the risk of side effects. Simultaneous use with aminoglycoside antibiotics should be avoided due to the increased toxic effect of aminoglycosides on the kidneys.
Thiosemicarbazone and 5-fluorouranil, as well as the simultaneous infusion of solutions containing sulfites, inhibit the activity of thiamine.
In case of unusual symptoms or pain in the legs, stop using the drug and consult a doctor.
It is imperative to follow the non-invasive treatments prescribed by your doctor (applying compresses, wearing supportive elastic stockings, dousing with cold water).
When using the drug, kidney function should be monitored.
The use of thiamine in high doses can distort the results in the determination of theophylline in serum by the spectrophotometric method and urobilinogen using the Ehrlich reagent.