Esfatil gel 40 g. tube


Manufacturer: Ukraine

Local treatment of acute and chronic venous insufficiency: varicose veins, superficial phlebitis and thrombophlebitis, hematomas and edema after blows and sprains.



Esfatil Composition
active ingredients: 1 g contains β-escin, in terms of 100% substance – 10 mg, sodium heparin in terms of heparin with an activity of 133 IU / mg – 0.75 mg (100 IU), epicuron 130 R, in terms of dry matter – 10 mg

excipients: isopropyl alcohol, methylparaben (methyl parahydroxybenzoate) (E 218), propylparaben (propyl parahydroxybenzoate) (E 216), carbomer, glycerin, 15% ammonia solution, lavender oil, purified water.

Esfatil Dosage form

Basic physical and chemical properties: yellowish gel, uniform consistency, with a specific odor.

Pharmacotherapeutic group
Medicines used for varicose veins. Topical heparin or heparinoids. Heparin, combinations.

ATX code С05В А53.

The drug has anti-inflammatory, decongestant and analgesic effects, improves microcirculation and tissue trophism.

Heparin is an acidic mucopolysaccharide with a relative molecular weight of approximately 16,000 daltons. Refers to direct anticoagulants. It inhibits blood coagulation by inactivating coagulation factors (V, VII, IX factors and Hageman factor) and blockade of thrombin biosynthesis. The drug reduces platelet aggregation, inhibits hyaluronidase activity, and activates the process of fibrinolysis.

b-Escin by its physicochemical properties is an amorphous water-soluble mixture of isomers of triterpene saponins, which are obtained from horse chestnut seeds, Aesculus hippocastanum L. Angioprotective, capillary stabilizing, decongestant, anti-inflammatory agent. The mechanism of action of b-escin is due to the stabilization of lysosomal membranes, inhibition of the release of autolytic cellular enzymes that break down proteoglycans and enhance the biosynthesis of pain and inflammation mediators. The drug reduces capillary permeability and fragility, preventing transcapillary filtration of low molecular weight proteins, electrolytes and water into the intercellular space; accelerates the resorption of hematomas and reduces lymphostasis, improves venous-lymphatic circulation and increases the tone of the venous wall, which prevents venous congestion and thrombosis in varicose nodes (especially the lower extremities), reduces peripheral edema, feeling of heaviness, fatigue, tension and pain in the problem area.

Esfatil Pharmacokinetics
Has not been studied.

Local treatment of acute and chronic venous insufficiency: varicose veins, superficial phlebitis and thrombophlebitis, hematomas and edema after strokes and sprains.

Hypersensitivity to the components of the drug. Trophic leg ulcers, bleeding, open and / or infected wounds, hemorrhagic diathesis, purpura, thrombocytopenia, hemophilia, bleeding tendency. Childhood.

Special security measures

Prevent contact with mucous membranes to avoid burning sensation.

Interaction with other medicinal products and other types of interactions
The anticoagulant effect of heparin is enhanced with the simultaneous use of anticoagulants, antiplatelet agents and NSAIDs. Ergot purpurea alkaloids, thyroxine, tetracycline, antihistamines, and nicotine reduce the effect of heparin.