Essliver forte capsules №30


Manufacturer: India

Fatty liver degeneration (including liver damage in diabetes), acute and chronic hepatitis, cirrhosis of the liver, pre-and post-operative treatment of the patient with surgical intervention on the liver and biliary tract, toxic liver lesions, pregnancy toxicosis, psoriasis, radiation syndrome.



Essliver forte Composition
active ingredients: 1 capsule contains natural phospholipids (EPL substance) 300 mg, nicotinamide 30 mg, pyridoxine hydrochloride 6 mg riboflavin 6 mg thiamine mononitrate 6 mg, tocopherol acetate 50% * 12 mg, cyanocobalamin 6 μg.

* Vit. E 93%, silicon dioxide precipitated, calcium carbonate, talc.

excipients: talc, magnesium-aluminum silicate hydrate, butylhydroxytoluene (E 321), sodium methylparaben (E 219), sodium propylparaben (E 217), Trilon B (Trilon B).

Essliver forte Dosage form

Basic physical and chemical properties: hard gelatin capsules No. “0” with a brown cap and a red body. The contents of the capsule are pinkish-yellow to orange powder. The presence of separate lobules from yellowish-white to brown color is allowed.

Pharmacotherapeutic group
Drugs used in diseases of the liver and biliary tract. Hepatotropic drugs. ATX code A05B A.

Essliver forte Pharmacodynamics
The main active ingredient of Essliver Forte® is natural phospholipids (EPL substance). Phospholipids, in their chemical structure, are similar to endogenous phospholipids, but surpass them due to the high content of polyunsaturated fatty acids. These molecules are incorporated primarily into the structures of cell membranes and facilitate the restoration of damaged liver tissue. Phospholipids exhibit a hepatoprotective effect when liver cells are damaged by viruses, alcohol, and toxic substances. In cells, the rate of intake and excretion of substances increases, restoration of enzyme systems and improvement of liver metabolism is ensured.

Phospholipids affect disturbed fat metabolism by regulating lipoprotein metabolism, resulting in neutral fats and cholesterol being converted into forms suitable for transport, especially by increasing the ability of high density lipoproteins (HDL) to bind cholesterol, and directed for further oxidation.

With the removal of phospholipids through the biliary tract, the lithogenic index decreases and bile stabilizes.

The vitamin complex performs the following functions: nicotinamide has a hypolipidemic effect and prevents fatty degeneration of the liver; pyridoxine, as a coenzyme, takes part in the metabolism of phospholipids, amino acids and proteins; thiamine is involved in carbohydrate metabolism; riboflavin is a cofactor of numerous respiratory enzymes tocopherol acts as an antioxidant at the level of the cell membrane, prevents the oxidation of unsaturated fatty acids.

When taken orally, more than 90% of the drug is absorbed in the small intestine. The main amount is cleaved by phospholipase-A to 1 acyl-LIZO-phosphatidylcholine, 50% of which is immediately split into polyunsaturated phosphatidylcholine even during absorption in the small intestine. Polyunsaturated phosphatidylcholine enters the bloodstream through the lymphatic pathways and then, mainly in combination with HDL, is transported to the liver. The maximum content of phosphatidylcholine in the blood 6-24 hours after ingestion averages 20%.

Non-alcoholic steatohepatitis, alcoholic steatohepatitis, acute and chronic hepatitis of various etiologies, liver cirrhosis. For pre- and postoperative treatment in surgical interventions on the liver and biliary tract. Psoriasis, radiation syndrome.

Hypersensitivity to the components of the drug. Allergic diseases. Intrahepatic cholestasis. Peptic ulcer and duodenal ulcer in the acute stage.

Special security measures

With caution and after consulting a doctor, use the drug for severe heart disease, kidney disease, an increased risk of thromboembolism, patients with a history of gastric ulcer and duodenal ulcer, neoplasms, nephrolithiasis, erythremia, erythrocytosis, hyperuricemia.

Interaction with other medicinal products and other types of interactions
Vitamin B6 weakens the effect of levodopa, prevents or reduces toxic manifestations that are observed with the use of isoniazid and other anti-tuberculosis drugs.

Para-aminosalicylic acid (PASK), cimetidine, calcium preparations, ethanol reduce the absorption of vitamin B12.

Riboflavin is incompatible with streptomycin and reduces the effectiveness of antibacterial drugs (oxytetracycline, doxycycline, erythromycin, tetracycline and lincomycin). The tricyclic antidepressants, imiprimine and amitriptyline, inhibit riboflavin metabolism, especially in the heart tissues.

It is not recommended to prescribe together with other multivitamin preparations, since the latter may overdose in the body.

Vitamin E should not be used together with iron and silver preparations, agents with an alkaline medium (sodium bicarbonate, trisamine), indirect anticoagulants (dicumarin, neodikumarin).