Felodip (felodipine) tablets with prolonged release 2.5 mg. №30


Manufacturer: CzechRepublic

Arterial hypertension. Preventive treatment of chronic stable angina.



Felodip 2.5 mg Storage
active substance: felodipine;

1 tablet contains 2.5 mg or 5 mg or 10 mg of felodipine;

excipients: lactose monohydrate, microcrystalline cellulose, hypromellose, povidone, propyl gallate, colloidal anhydrous silica, magnesium stearate;

tablet shell 2.5 mg: hypromellose, iron oxide yellow (E 172), titanium dioxide (E 171), talc, propylene glycol;

tablet shell 5 mg and 10 mg: hypromellose, iron oxide red (E 172), iron oxide yellow (E 172), titanium dioxide (E 171), talc, propylene glycol.

Felodip 2.5 mg Dosage form
Modified-release tablets.

Basic physical and chemical properties:

2.5 mg tablets: coated tablets, yellow, round, biconvex, 9 mm in diameter, with an imprint of “2.5” on one side;

5 mg tablets: film-coated tablets, light pink, round, biconvex, 9 mm in diameter, with an imprint of “5” on one side;

10 mg tablets: film-coated tablets, reddish-brown, round, biconvex, 9 mm in diameter, imprinted with “10” on one side.

Felodip 2.5 mg Pharmacotherapeutic group
Selective calcium channel blockers with a predominant effect on blood vessels. Dihydropyridine derivatives. ATX code C08C A02.

Pharmacological properties


Felodipine is a vasoselective calcium channel blocker that lowers blood pressure by reducing peripheral vascular resistance. At therapeutic doses, felodipine selectively affects the smooth muscle of the arterioles, does not directly affect the contractility and conductivity of the heart. The drug does not affect venous smooth muscle and adrenergic vasomotor mechanisms, and therefore felodipine is not associated with symptoms of orthostatic hypotension. Felodipine has its own moderate natriuretic and diuretic effects, and therefore does not cause fluid retention.

Felodipine is effective in various degrees of hypertension. It can be used as monotherapy or in combination with other antihypertensive drugs, such as: β-blockers, diuretics or ACE inhibitors to enhance the antihypertensive effect. Felodipine lowers systolic and diastolic blood pressure and can be prescribed in case of isolated systolic hypertension. Felodipine retains its antihypertensive efficacy also in combination with nonsteroidal anti-inflammatory drugs.

Felodipine has antianginal and anti-ischemic effects due to the effect on the balance between myocardial oxygen consumption and supply. Felodipine reduces the resistance of coronary vessels. Blood flow through the coronary vessels and oxygen saturation of the myocardium are also increased due to dilatation of the epicardial arteries and arterioles. Felodipine effectively prevents the formation and development of coronary vasospasm. The decrease in systemic blood pressure caused by felodipine reduces postload on the left ventricle and reduces myocardial oxygen demand.


Preventive treatment of chronic stable angina.

Hypersensitivity to felodipine and to other dihydropyridines (theoretical risk of cross-reactivity) or to other components of the drug.
Decompensated heart failure.
Unstable angina.
Acute myocardial infarction.
Dynamic obstruction of the external tract of the left ventricle.
Severe aortic / mitral stenosis.