Fenocit (dimetindene maleatee) oral drops 1 mg/ml. 20 ml.


Manufacturer: Ukraine/Spain

Symptomatic treatment of allergic diseases: urticaria, seasonal (hay fever) and year-round allergic rhinitis, allergies to medicines and food. Itching of various origins, except for those associated with cholestasis. Itching in diseases with skin rashes, such as chickenpox. Insect bite. An adjuvant for eczema and other itchy dermatoses of allergic origin.



Fenocit Storage:

active substance: dimethindene maleate;

1 ml contains dimethindene maleate 1 mg;

Excipients: benzoic acid (E 210), citric acid, monohydrate, sodium hydrogen phosphate dodecahydrate, disodium edetate, propylene glycol, sodium saccharin, purified water.

Fenocit Dosage form.

Oral drops.

Basic physical and chemical properties: transparent colorless solution, practically without smell.

Pharmacotherapeutic group. Antihistamines for systemic use. Substituted alkylamines. ATX code R06A B03.

Fenocit Pharmacological properties.


Dimethindene maleate is a derivative of phenindene. It is a histamine antagonist at the level of H1 ‑ receptors.

Has antikinin, weak anticholinergic and sedative effect, has no anti-nausea effect. Reduces the increased capillary permeability associated with immediate allergic reactions. In combination with histamine H2-receptor antagonists, the drug inhibits almost all effects of histamine on blood circulation.


The systemic bioavailability of dimethindene in the form of oral drops is approximately 70%. After oral administration, the maximum concentration of dimethindene in blood plasma is reached within 2 hours. The half-life is almost 6 hours.

At concentrations of 0.09 to 2 μg / ml, the binding of dimethindene to plasma proteins is approximately 90%. In the body, the drug is metabolized by hydroxylation and methoxylation. Dimethindene and its metabolites are excreted in bile and urine. 5-10% of the dose is excreted in the urine unchanged.

Clinical characteristics.


Symptomatic treatment of allergic diseases: urticaria, seasonal (hay fever) and perennial allergic rhinitis, allergies to drugs and food.

Itching of various origins other than cholestasis. Itching in diseases with skin rashes such as chickenpox. Insect bites.

An aid in eczema and other itchy dermatoses of allergic origin.


Hypersensitivity to dimethindene maleate or to any other component of the drug. The patient has a stenosis of the duodenum / pylorus.

Interaction with other drugs and other types of interactions.

With concomitant use of drugs that suppress the central nervous system (CNS), such as opioid analgesics, anticonvulsants, antidepressants (tricyclic antidepressants and monoamine oxidase inhibitors), other antihistamines, antiemetics, antipsychotics, antiemetics, antispasmodics , which can lead to undesirable consequences or even to life-threatening.

Concomitant use of procarbazine and antihistamines should be performed with caution to minimize the risk of CNS depression or possible potentiation.

Features of application.

As with other antihistamines, caution should be exercised when using the drug in patients with angle-closure glaucoma, urinary incontinence, including prostate hypertrophy, and chronic lung disease.

As with all H1-receptor antagonists and partially H2-receptor antagonists, this drug should be used with caution in patients with epilepsy. Antihistamines can cause agitation in children.