infection of the respiratory system; infections of the genitourinary system; infection of the digestive tract; skin and soft tissue infections.
Flemoxin 250 mg Storage
active substance: amoxicillin;
1 tablet contains amoxicillin (in the form of amoxicillin trihydrate) – 125 mg, 250 mg, 500 mg, 1000 mg;
Excipients: microcrystalline cellulose, microcrystalline cellulose and carmellose sodium, crospovidone, vanillin, mandarin flavor, lemon flavor, saccharin, magnesium stearate.
Flemoxin 250 mg Dosage form
Main physical and chemical properties: tablets of white or almost white color (light yellow shade is possible at storage), oblong form with an engraving “231” for Flemoksin Solutabu® 125 mg, “232” – for Flemoksin Solutabu® 250 mg, “234” – for Flemoxin Solutabu® 500 mg, “236” – for Flemoxin Solutabu® 1000 mg, marked
on one side and a dash on the other side.
Flemoxin 250 mg Pharmacotherapeutic group
Antimicrobials for systemic use. Beta-lactam antibiotics. Broad-spectrum penicillins. Amoxicillin. ATX code J01CA04.
Infections caused by drug-sensitive microorganisms:
organs of the genitourinary system;
organs of the gastrointestinal tract (GI tract);
skin and soft tissues.
Hypersensitivity to the active substance, to other penicillins or to any of the excipients.
Severe immediate hypersensitivity reaction (eg, anaphylaxis) to another beta-lactam antibiotic (eg, cephalosporin, carbapenem, or monobactam) in the history.
Interaction with other medicinal products and other forms of interaction
Concomitant use of allopurinol and amoxicillin increases the risk of allergic skin reactions.
Isolated cases of an increase in the international normalized ratio (INR) have been reported in patients taking amoxicillin and acenocoumarol or warfarin concomitantly. If necessary, prothrombin time or ESR should be closely monitored with the addition or discontinuation of amoxicillin. In addition, it may be necessary to adjust the dose of oral anticoagulants.
Penicillins may reduce the excretion of methotrexate, which may increase the toxicity of the latter.
Non-enzymatic reactions with glucose oxidase should be used for amoxicillin treatment to determine urinary glucose levels, as non-enzymatic methods may give false positive results.
Probenecid, phenylbutazone, oxyfenbutazone, to a lesser extent acetylsalicylic acid, indomethacin and sulfinpyrazone, inhibit the tubular secretion of penicillin drugs, which leads to an increase in the half-life and concentration of amoxicillin in blood.
Like other antibiotics, amoxicillin can affect the intestinal flora, leading to decreased estrogen reabsorption and reduced efficacy of combined oral contraceptives.
Drugs that have a bacteriostatic function (tetracycline antibiotics, macrolides, chloramphenicol) can neutralize the bactericidal effect of amoxicillin. Concomitant use of aminoglycosides is possible (synergistic effect).