Treatment of functional disorders of the lower urinary tract in benign prostatic hyperplasia.
active substance: 1 capsule contains tamsulosin hydrochloride 0.400 mg
granule core: microcrystalline cellulose, methacrylate copolymer (type A) 30% dispersion (containing polysorbate 80 and sodium lauryl sulfate), triethyl citrate, talc
granule shell: methacrylate copolymer (type A) dispersion 30% (containing polysorbate 80 and sodium lauryl sulfate), triethyl citrate, talc
capsules (body composition): iron oxide red (E172), titanium dioxide (E 171), iron oxide yellow (E172), gelatin
FLOSIN DOSAGE FORM
Modified release hard capsules.
FLOSIN MAIN PHYSICAL AND CHEMICAL PROPERTIES:
hard gelatin capsule with an orange body and an olive-colored lid. The capsule is filled with white or almost white granules.
Suction. Tamsulosin is almost completely absorbed in the intestine. In the case of using tamsulosin immediately after a meal, its absorption decreases. In order for Flosin to be absorbed at about the same rate all the time, it must be used at the same time after a meal. The pharmacokinetic parameters of tamsulosin vary in direct proportion to the dose. After a single dose on a full stomach, Flosin reaches its maximum plasma concentration after 6:00 in an equilibrium state, occurs on the 5th day of treatment, the Cmax value is approximately two-thirds higher than the Cmax value after taking a single dose.
Distribution. In humans, tamsulosin binds to blood plasma proteins by 99%. The volume of distribution is insignificant (approximately 0.2 l / kg).
Treatment of functional disorders of the lower urinary tract in benign prostatic hyperplasia (BPH).
Hypersensitivity to tamsulosin hydrochloride, including drug-induced angioedema, or to any of the excipients, a history of orthostatic hypotension, severe hepatic impairment.
INTERACTION WITH OTHER DRUGS AND OTHER INTERACTIONS
The study of the interaction of tamsulosin with other drugs was carried out only in adults.
With the simultaneous use of tamsulosin hydrochloride with atenolol, enalapril or theophylline, drug interactions were not observed. Simultaneous use with cimetidine increases, and with furosemide reduces the concentration of tamsulosin in the blood plasma, but since these levels remain within the normal range, there is no need for a special dose adjustment of tamsulosin.
In in vitro studies, diazepam, propranolol, trichloromethiazide, chlormadinone, amitriptyline, diclofenac, glibenclamide, simvastatin and warfarin do not affect the free fraction of tamsulosin in human blood plasma. Similarly, tamsulosin does not alter the level of free fractions of diazepam, propanolol, trichloromethiazide and chlormadinone in human blood plasma.