Diseases of the skin in which shows the treatment with corticosteroids (eczema, psoriasis vulgaris, allergic dermatitis).
Focort cream Composition
active substance: triamcinolone;
1 g of cream contains micronized triamcinolone acetonide 1 mg;
excipients: cetylpyridinium chloride, propylene glycol, white soft paraffin, liquid paraffin, solid paraffin, cetostearyl alcohol, purified water.
Focort cream Dosage form
Basic physical and chemical properties: white cream of uniform consistency.
Focort cream Pharmacotherapeutic group
Corticosteroids for dermatological use. Triamcinolone. ATX code D07A B09.
The active ingredient of the cream is triamcinolone acetonide, a glucocorticosteroid containing fluorine, which, when applied topically, exhibits anti-inflammatory, anti-allergic and antipruritic effects.
The pharmacological action of glucocorticosteroids is based on the regulation of the synthesis of specific body proteins and ensuring the body’s adaptability to stressful situations by reducing glucose utilization and increasing gluconeogenesis. They contribute to the deposition of glycogen, primarily in the liver, by increasing the secretion of insulin in conditions of hyperglycemia. Reduce synthesis and enhance catabolism of proteins in muscle, skin and bone tissues; promote lipolysis. Narrow blood vessels, reduce their permeability and tissue swelling.
Numerous glucocorticosteroid receptors are also found in the tissues of the brain and heart. Glucocorticosteroids increase β-adrenergic reactions in the lungs, promote bronchodilation and reduce vascular resistance in the lungs.
Esterification of the glucocorticosteroid molecule with fatty acids in positions 17 and 21 significantly enhances its effect on the skin. The location of cyclic acetonide in 16 and 17 positions enhances the local anti-inflammatory effect without affecting the systemic effect of glucocorticosteroids. Fluorine further enhances the local activity of the drug.
Triamcinolone penetrates well into the deep layers of the skin, partially enters the bloodstream. When using an occlusive dressing on the affected skin areas, it is absorbed in an amount sufficient to provide a systemic effect. Glucocorticosteroids are rapidly distributed in body tissues. The main metabolite of triamcinolone, 6-β-hydroxytriamcinolone, is excreted by the liver, kidneys, feces and urine in equal proportions. The half-life from blood plasma is about 5 hours, the half-life is 18-36 hours.
Skin diseases for which corticosteroid treatment is indicated (eczema, psoriasis vulgaris, allergic dermatitis).
Hypersensitivity to triamcinolone acetonide or to drug excipients. Tuberculosis, viral skin lesions, especially with herpes simplex and chickenpox; skin manifestations of syphilis, skin reactions after vaccination, perianal and genital itching, widespread plaque psoriasis, varicose veins, leg ulcers; facial skin lesions (rosacea, acne vulgaris, perioral dermatitis); diaper rash caused by wet diapers; use as monotherapy without specific treatment for fungal and bacterial skin infections, treatment of dry skin peeling, skin cancer, children under 1 year old.
Interaction with other medicinal products and other types of interactions
When steroids are used topically, interactions with other drugs are unknown.