Folic acid tablets 0.001 №30


Manufacturer: Ukraine

Treatment and prevention of anemia associated with folic acid deficiency: macrocytic anemia and leukopenia caused by drugs and ionizing radiation; megaloblastic anemia, postresection anemia, sideroblastic anemia in elderly patients; anemia in inflammatory bowel diseases (Crohn’s disease, ulcerative colitis), malabsorption syndrome (gluten enteropathy or celiac disease), sprue; prevention of fetal birth defects: neural stem defects (hydrocephalus, brain hernias, “cleft palate”, “hare lip”) in women who are planning a pregnancy and are at risk; long-term treatment with folic acid antagonists (methotrexate, sulfamethoxazole-trimethoprim combination), anticonvulsants (phenytoin, primidone, phenobarbital); folic acid deficiency associated with an unbalanced or unsatisfactory diet; treatment of male infertility due to reduced spermatogenesis (oligospermia); polyneuritis and polyneuropathy, including alcohol etiology.



Folic №30 Composition
active substance: folic acid;

1 tablet contains 1 mg folic acid;

excipients: glucose monohydrate, stearic acid.

Folic №30 Dosage form

Basic physical and chemical properties: round tablets with a flat surface and a chamfer, light yellow color. Inhomogeneity of coloring and slight inclusions are allowed.

Folic №30 Pharmacological group
Antianemic agents. Folic acid and its derivatives. ATX code B03B B01.

Pharmacological properties


Folic acid belongs to the B vitamins and is synthesized in the human body by the intestinal microflora. After taking the drug, folic acid is reduced to tetrahydrofolic acid, which is a coenzyme involved in various metabolic processes. It is necessary for the normal development of other blood cells, including the formation and maturation of megaloblasts and the formation of normoblasts. In combination with vitamin B12 (cyanocobalamin), it stimulates the process of hematopoiesis, partially – erythropoiesis. Participates in the synthesis of amino acids (including methionine, serine, glycine and histidine), nucleic acids, purines, pyrimidines, and takes part in the metabolism of choline.

During pregnancy, folic acid protects the body from teratogenic factors. With a deficiency of folic acid, a megaloblastic type of hematopoiesis develops, in pregnant women this can cause the development of congenital malformations in the fetus (neural tube defects, hydrocephalus, etc.). The most important consequence of folate deficiency is a decrease in the ability to regenerate damaged tissue.


After oral administration, folic acid is well and completely absorbed from the digestive tract, mainly in the upper part of the duodenum and the proximal part of the small intestine. Almost completely binds to blood plasma proteins. About 87% of folates that have entered the blood are in erythrocytes, 10-13% in serum. From the blood, folates enter the liver, where they are activated by the enzyme dihydrofolate reductase, converting to tetrahydrofolic acid. The maximum concentration in the blood is reached after 30-60 minutes. It is excreted by the kidneys mainly in the form of metabolites; if the dose taken significantly exceeds the daily requirement for folic acid, then the kidneys begin to secrete the vitamin unchanged. It is excreted in the urine by glomerular filtration; 5 mg of orally taken folic acid is excreted from the body after 5 hours. During hemodialysis, it is removed from the circulatory system.

Macrocytic anemia, in particular, megaloblastic anemia in pregnant women; for the treatment of sprue in order to normalize hematopoiesis, eliminate or reduce the clinical manifestations of the disease. Anemia and leukopenia caused by ionizing radiation, chemicals, including drugs; anemia as a result of resection of the stomach or part of the intestine, megaloblastic anemia caused by intestinal tuberculosis and chronic gastroenteritis (with these diseases, it is indicated without the development of anemia), pernicious anemia, pellagra.

Folic acid deficiency associated with an unbalanced or inadequate diet.

As an adjuvant for depression and increased anxiety; in the treatment of cervical dysplasia.

Hypersensitivity to folic acid or to drug components, vitamin B12 deficiency, malignant neoplasms, pernicious anemia, untreated cobalamin deficiency.