Fotil eye drops 5 ml. vial №1


Manufacturer: Finland

The treatment of open-angle, angle-closure glaucoma, awakino and secondary glaucoma. As part of a comprehensive treatment for the treatment of glaucoma, for reducing intraocular pressure after ophthalmic operations, for the treatment of glaucoma after cataract removal, and for reducing increased intraocular pressure in patients for whom monotherapy is not sufficient. Recommended for use only as directed by a doctor.



Fotil Storage
active substances: pilocarpine hydrochloride; timolol;

1 ml of eye drops contains pilocarpine hydrochloride 40 mg; timolol maleate in terms of timolol 5 mg;

1 ml contains 36 drops;

1 drop contains timolol 0.14 mg, pilocarpine hydrochloride 1.11 mg;

excipients: benzalkonium chloride; citric acid, monohydrate; sodium citrate; hypromellose; water for injections.

Fotil Dosage form
Eye drops.

Basic physical and chemical properties: transparent, colorless solution.

Fotil Pharmacotherapeutic group
Drugs used in ophthalmology. Antiglaucoma and miotic drugs. Pilocarpine, combinations. ATX code S01E B51.

Pharmacological properties


Pilocarpine is a parasympathomimetic agent that, like acetylcholine, stimulates muscarinic receptors. When applied topically to the eyes, pilocarpine causes a decrease in intraocular pressure, pupil narrowing and accommodation spasm. The decrease in intraocular pressure is thought to be caused by the contraction of the ciliary muscle and the smooth muscles of the iris, which increases the angle of the anterior chamber and changes the configuration of the trabecular meshwork, thus facilitating the outflow of ocular fluid. For a long time, pilocarpine was used as a miotic to reduce pupils and reduce intraocular pressure in almost all types of glaucoma.

The L-isomer of timolol in Fotil® Forte is a β-blocker that effectively blocks the binding of sympathomimetic neurotransmitters to β-1 and β-2 adrenergic receptors. Timolol has no significant sympathomimetic or local action on cell membrane stabilization. Timolol is also used to treat high blood pressure and angina, but the main indication for its use is glaucoma. The decrease in intraocular pressure occurs due to a decrease in the formation of intraocular fluid. In the eye, the drug locally penetrates the target tissue, namely the ciliary body, where intraocular fluid is formed. It is not known whether it still affects the blood vessels of the anterior part of the eye in any way, but there is evidence that with decreasing intraocular pressure, blood circulation in the retina improves. Timolol, like many other β-blockers, has a long postreceptor effect; the adrenergic receptor cannot mediate the agonist effect, although timolol has undergone a breakdown period at that time.

Treatment of open-angle, closed-angle glaucoma, aphakia and secondary glaucoma. As part of a comprehensive treatment of glaucoma, to reduce intraocular pressure after ophthalmic surgery, to treat glaucoma after cataract removal and to reduce elevated intraocular pressure in patients for whom monotherapy is insufficient.

Recommended for use only on prescription.

Hypersensitivity to the active substances or to any of the excipients. β-blockers (timolol) is contraindicated in patients with second- and third-degree antrioventricular block without cardiac pacemaker, with sinus bradycardia, with the syndrome of weakness of the sinus node, synauricular block, severe heart failure, cardiogenic shock, with reactive shock, with reactive shock, bronchial asthma or a history of severe bronchial asthma, with severe chronic obstructive pulmonary disease.

Cholinergic drugs (pilocarpine) are contraindicated in acute iritis and in conditions when miosis should be avoided.

Paradoxical reaction to Fotil® forte or pilocarpine in congestive glaucoma; acute inflammatory diseases of the eye tissue.

Miotic drugs are contraindicated in the presence of neovascularization of the iris.