Prevention of thrombosis in the pre-and postoperative period. Prevention of proximal deep vein thrombosis in patients with conditions requiring bed rest, including, among others, congestive heart failure (NYHA class i or IV), acute respiratory failure, or acute infections, if there is a provoking risk factor for venous thromboembolism (such as age 75 or older, obesity, cancer, or a history of venous thromboembolism (VTE)). Treatment of deep vein thrombosis, as well as long-term prevention of recurrent venous thromboembolic processes in cancer patients. Prevention of blood clotting in the extracorporeal circulation system during hemodialysis or hemofiltration in patients with chronic or acute renal failure. Treatment of venous thromboembolism with clinical manifestations of deep vein thrombosis( DVT), pulmonary embolism, or both of these diseases. Unstable angina and myocardial infarction without a q wave (unstable course of coronary heart disease), the drug is used simultaneously with aspirin.