Skin diseases that are sensitive to corticosteroids (eczema, vulgar psoriasis, allergic dermatitis).
active substance: triamcinolone;
1 g of ointment contains 1 mg of triamcinolone acetonide;
excipients: methyl parahydroxybenzoate (E 218), stearic acid, polysorbate 60, cetyl alcohol, liquid paraffin, glycerin (85%), purified water.
Ftorocort Dosage form
Basic physical and chemical properties: white or almost white homogeneous ointment, practically odorless.
Ftorocort Pharmacotherapeutic group
Corticosteroids for dermatological use. Triamcinolone. ATX code D07A B09.
The active substance of the ointment is triamcinolone acetonide – GCS containing fluoride and, when applied topically, exhibits anti-inflammatory, anti-allergic and antipruritic effects.
The pharmacological action of glucocorticosteroids is based on the regulation of the synthesis of specific body proteins and ensuring the body’s adaptability to stressful situations by reducing glucose utilization and increasing gluconeogenesis (hyperglycemia). They contribute to the deposition of glycogen, primarily in the liver, by increasing the secretion of insulin in conditions of hyperglycemia. Reduce synthesis and enhance catabolism of proteins in muscle, skin and bone tissues, promote lipolysis. Narrow blood vessels, reduce their permeability and tissue swelling.
Numerous GCS receptors are also found in the tissues of the brain and heart. GCS increase β-adrenergic reactions in the lungs, dilate the bronchi and reduce vascular resistance in the lungs.
In high doses, they inhibit the secretion of corticotropin, with adrenocorticosteroid insufficiency, they increase glomerular filtration and diuresis; cut ulcerative lesions of the mucous membranes. In large doses, they show anti-allergic and anti-inflammatory properties.
Esterification of the GCS molecule with fatty acids in positions 17 and 21 significantly enhances its effect on the skin. The location of cyclic acetonide in positions 16 and 17 enhances the local anti-inflammatory effect without affecting the systemic effect of GCS. Fluorine further enhances the local activity of the drug.
Triamcinolone penetrates well into the deep layers of the skin, partially enters the bloodstream. When using an occlusive dressing on the affected skin areas, it is absorbed in an amount sufficient to provide a systemic effect. GCS are rapidly distributed in body tissues. The main metabolite of triamcinolone, 6-β-hydroxytriamcinolone, is excreted by the liver, kidneys, feces and urine in equal proportions. The plasma half-life is about 5 hours, the half-life is 18-36 hours.
Skin diseases sensitive to corticosteroids (eczema, psoriasis vulgaris, allergic dermatitis).
Hypersensitivity to triamcinolone acetonide or to an auxiliary substance of the drug.
The drug should not be applied to the eyes or skin around the eyes.
Use as monotherapy without specific treatment for fungal and bacterial skin infections; tuberculosis; viral skin lesions, especially with herpes simplex and chickenpox; with parasitic infections (scabies), skin manifestations of syphilis; skin reactions after vaccination; perianal and genital pruritus leg ulcer varicose veins common
plaque psoriasis; facial skin lesions (rosacea, acne vulgaris, perioral dermatitis); diaper rash caused by wet diapers; treating dry skin peeling and applying ointment to the chest
just before breastfeeding, children under 1 year of age.