Furagin is used for the treatment of acute and chronic diseases of the genitourinary system: pyelonephritis; cystitis; urethritis; prostatitis; postoperative infections of the genitourinary system.
active substance: furagin;
1 tablet contains furagin 50 mg;
excipients: lactose monohydrate; sugar; modified corn starch; stearic acid; polysorbate.
Furagyn Dosage form
Main physical and chemical properties: flat-cylindrical bevelled tablets from yellow to yellow with an orange tinge.
Furagyn Pharmacotherapeutic group
Antimicrobials for systemic use. Nitrofuran derivatives. Furazidine.
ATX code J01X E03.
Furagin is a nitrofuran antibacterial agent with bacteriostatic action. It is effective against gram-positive (Staphyloccocus epidermidis, Staphyloccocus aureus, Staphyloccocus faecalis), gram-negative (Enterobacteriaceae, Klebsiella spp, Eschrichia coli) bacteria. , as well as other biochemical processes in the bacterial cell, which in turn causes disruption of the cytoplasmic membrane and cell membrane of the bacterium.
Absorption. Furagin is well absorbed from the digestive tract. Absorption of the drug mainly takes place from the distal part of the small intestine by passive diffusion (exceeds the absorption from the proximal part several times). After a single dose of 200 mg, the maximum concentration of furagin is reached in blood plasma after 30 minutes, maintained at this level for 1 hour, then slowly decreases. The bacteriostatic concentration of furagin in blood plasma is maintained for 8-12 hours. Furagin binds to plasma proteins.
Metabolism / elimination. 10% of the dose is biotransformed in the liver and kidneys. When renal function is impaired, most of the applied dose is biotransformed.
The half-life of furagin is short (about 1 hour). Furagin is excreted by the kidneys, mainly by tubular secretion (85%). 8-13% of furagin in unchanged form enters the urine, where its concentration is many times higher than the minimum inhibitory concentration for most sensitive bacteria. The maximum concentration of furagin in urine is 5.7 μg / ml.
Furagin penetrates the placental barrier well.
Acute and chronic urinary tract infections: pyelonephritis, cystitis, urethritis; prostatitis; postoperative infections of the genitourinary system.
Hypersensitivity to furagin, to derivatives of the nitrofuran group or to excipients of the drug;
severe renal insufficiency (creatinine clearance less than 30 ml / min);
severe liver failure;
polyneuropathy (including diabetic);
glucose-6-phosphate dehydrogenase deficiency (risk of hemolysis);
porphyria (diseases caused by metabolic disorders of hemoglobin);
rare congenital galactose intolerance, lactase deficiency or glucose-galactose malabsorption;
sucrose / isomaltase / lactase deficiency, fructose / lactose intolerance.
It is contraindicated in patients on hemodialysis or peritoneal hemodialysis.
Contraindicated for children (under 18 years).
Do not use during pregnancy and breastfeeding.
Furagin is not recommended for urosepsis and renal parenchymal infections.