Treatment of persistent edema, if they are associated with secondary hyperaldosteronism; treatment of conditions including chronic heart failure and cirrhosis of the liver. Application Foresta for controlling hypertension should be restricted to patients with marked hyperaldosteronism. Furostim should be prescribed when titration of the components of the drug separately shows that this drug is useful for treatment.
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Furostim capsules Composition
active ingredients: 1 capsule contains spironolactone 50 mg furosemide 20 mg
excipients: mannitol (E 421), croscarmellose sodium, colloidal silicon dioxide, sodium lauryl sulfate, povidone, magnesium stearate
the shell of the gelatin capsule contains methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), glycerin, silicon dioxide, sodium lauryl sulfate, glacial acetic acid, gelatin.
Furostim capsules Dosage form
Basic physical and chemical properties:
hard gelatin capsule No. 2 with a transparent lid and body, containing a homogeneous powder, partially compressed, of white or almost white color.
Furostim capsules Pharmacological group
Combined diuretics. Furosemide in combination with potassium-sparing drugs. ATX code С0ЗЕ В01.
Furostim is a combined preparation containing the short-acting diuretic furosemide and the long-acting aldosterone antagonist spironolactone.
Furosemide is a fast-acting loop diuretic that has a relatively strong and short-term diuretic effect. Furosemide blocks the Na + K + 2Cl-cotransporter located in the basement membranes of the cells of the thick segment of the ascending part of Henle’s loop: the effectiveness of the saluretic action of furosemide, therefore, depends on whether the drug enters the tubules at the lumen by the anion transport mechanism. The diuretic effect occurs as a result of inhibition of sodium chloride reabsorption in this segment of the Henle loop. As a result, fractional sodium excretion can reach 35% of sodium glomerular filtration rate. Secondary effects of increased sodium excretion are increased urinary excretion (due to osmotically bound water) and increased distal tubular potassium secretion. The excretion of calcium and magnesium ions also increases. Furosemide causes dose-dependent stimulation of renin-angiotensin-aldosterone. In heart failure, furosemide leads to an acute decrease in cardiac preload (by narrowing the capacitive venous vessels). This early vascular effect is prostaglandin-mediated and suggests adequate renal function with renin-angiotensin activation and intact prostaglandin synthesis. In addition, due to its inherent natriuretic effect, furosemide reduces vascular reactivity relative to catecholamines, which is increased in patients with arterial hypertension.
Since the drug is combined, the pharmacokinetics have not been studied.
Treatment of persistent edema if associated with secondary hyperaldosteronism; Treatment of conditions including chronic heart failure and cirrhosis of the liver.
The use of Furostim for the control of arterial hypertension should be limited to patients with severe hyperaldosteronism. Furostim is prescribed when titration of the constituents of a drug individually indicates that the drug is useful for treatment.
Hypersensitivity to furosemide, spironolactone, sulfamides or sulfonamide derivatives, or to an auxiliary substance of the drug.
Hypovolemia or dehydration of the body (with or without concomitant arterial hypotension) impaired renal function and CC below 30 ml / min per 1.73 m2 of body surface area anuria or renal failure in the form of anuria, if there is no therapeutic response to furosemide renal failure due to poisoning nephrotoxic or hepatotoxic drugs or renal failure associated with hepatic coma hyperkalemia severe hypokalemia severe hyponatremia Addison’s disease pregnancy or breastfeeding.