Glutargin is prescribed for such diseases: in the complex therapy of acute and chronic hepatitis; cirrhosis; hepatic encephalopathy; leptospirosis; hepatic coma; drug and chemical poisoning; alcohol poisoning; alcohol withdrawal syndrome; prevention of alcohol intoxication; pathology of the hepatobiliary system in late-term pregnant women.
Glutargyn powder Composition
active substance: arginine glutamate;
1 packet (3 g) contains arginine glutamate 1 g;
auxiliary substances: glycine, beckon (E 421), citric acid, aspartame (E 951), lemon flavoring containing maltodextrin, gum arabic, citric acid.
Glutargyn powder Dosage form
Powder for oral solution.
Basic physical and chemical properties: powder from white to white with a yellowish shade of color with a fruity odor.
Glutargyn powder Pharmacotherapeutic group
Drugs used for liver diseases, lipotropic substances. Arginine glutamate. ATX code A05B A01.
Glutargin is a salt of arginine and glutamic acid.
In case of alcohol intoxication, the drug stimulates the utilization of alcohol in the monooxygenase system of the liver, prevents the inhibition of the key enzyme for the utilization of ethanol – alcohol dehydrogenase; accelerates the inactivation and elimination of toxic products of ethanol metabolism as a result of an increase in the formation and oxidation of succinic acid; reduces the depressing effect of alcohol on the central nervous system (CNS) due to the neurotransmitter properties of excitatory glutamic acid. Due to these properties, the drug exhibits antitoxic and sobering effects.
The drug also has hepatoprotective and hypoammonoemic properties. The hepatoprotective effect of the drug is due to its antioxidant, antihypoxic and membrane stabilizing properties, as well as a positive effect on the processes of energy supply in hepatocytes. The hypoammonaemic effects of the drug are realized by activating the neutralization of ammonia in the ornithine cycle of urea synthesis, binding ammonia to non-toxic glutamine, as well as enhancing the excretion of ammonia from the central nervous system and its excretion from the body. Thanks to these properties of the drug, the general toxic, including neurotoxic effects of ammonia are reduced.
In experimental studies on animals, the drug did not show embryotoxic, gonadotoxic, mutagenic and teratogenic effects, did not cause allergic and immunotoxic reactions.
Has not been investigated.
Prevention of alcohol intoxication and hepatotoxic effects. Treatment of acute alcoholic intoxication of mild and moderate severity, as well as in the complex therapy of post-intoxication disorders after acute alcoholic poisoning of severe degree.
Hypersensitivity to the components of the drug. A state of fever, increased excitability, severe impairment of the filtration (nitrogen-excreting) function of the kidneys.
Interaction with other medicinal products and other types of interactions
The effect of the drug on insulin secretion is increased with concomitant administration of aminophylline. The drug can enhance the effect of antiaggregatory agents (dipyridamole). Prevents and weakens neurotoxic phenomena that may occur with the use of isoniazid. Weakens the effect of vinblastine.