Glutargin is prescribed for such diseases: in the complex therapy of acute and chronic hepatitis; cirrhosis; hepatic encephalopathy; leptospirosis; hepatic coma; drug and chemical poisoning; alcohol poisoning; alcohol withdrawal syndrome; prevention of alcohol intoxication; pathology of the hepatobiliary system in late-term pregnant women.
GLUTARGYN №30 COMPOSITION
active substance: 1 tablet contains arginine glutamate 250 mg (0.25 g) or 750 mg (0.75 g)
Excipients: dosage 250 mg – microcrystalline cellulose, crospovidone, croscarmellose sodium, calcium stearate, dosage 750 mg – microcrystalline cellulose, crospovidone, calcium stearate.
GLUTARGYN №30 DOSAGE FORM
GLUTARGYN №30 MAIN PHYSICAL AND CHEMICAL PROPERTIES
dosage of 250 mg – tablets of white color, with a flat surface, with a scored and chamfering dosage of 750 mg – tablets of white color, elongated shape with a chamfer, with a notch.
Drugs used for liver diseases, lipotropic substances. Hepatotropic drugs. Arginine glutamate. ATX code A05B A01.
Pharmacological. Glutargin is a salt of arginine and glutamic acid, which play an important role in providing biochemical processes of neutralization and excretion of a highly toxic metabolite of nitrogenous substances – ammonia from the body. The hypoammonaemic effects of the drug are realized by activating the neutralization of ammonia in the ornithine cycle of urea synthesis, binding of ammonia to non-toxic glutamine, as well as enhancing the excretion of ammonia from the central nervous system and its excretion from the body. Thanks to these properties of Glutargin, general toxic, including the neurotoxic effects of ammonia, are reduced.
Glutargin also has a hepatoprotective effect due to antioxidant, antihypoxic and membrane stabilizing properties, and has a positive effect on the processes of energy supply in hepatocytes.
In case of alcohol intoxication, Glutargin stimulates the utilization of alcohol in the monooxygenase system of the liver, prevents the inhibition of the key enzyme for the utilization of ethanol – alcohol dehydrogenase, accelerates the inactivation and elimination of toxic products of ethanol metabolism as a result of an increase in the formation and oxidation of succinic acid, and reduces the inhibitory effect of alcohol on the central nervous system due to the excitatory properties of neurotransmitter acid. Thanks to these properties, Glutargin exhibits antitoxic and sobering effects.
Glutargin does not exhibit embryotoxic, gonadotoxic, mutagenic and teratogenic effects, does not cause allergic and immunotoxic reactions.
Pharmacokinetics. Has not been investigated.
As part of the complex therapy of acute and chronic hepatitis of various etiologies, incl. In case of poisoning with hepatotropic poisons (pale toadstool, chemical and medicinal substances), with cirrhosis of the liver, leptospirosis.
Hepatic encephalopathy accompanied by hyperammonemia.
Acute alcohol poisoning of mild and moderate severity, hangover syndrome, post-intoxication disorders caused by alcohol intake.
Complications in the third trimester of pregnancy: late gestosis, including its severe forms – preeclampsia and eclampsia, placental insufficiency, chronic pathologies of the digestive system in pregnant women.
Hypersensitivity to the components of the drug. Fever, hyperexcitability, severe impairment of the filtration (nitrogen-excreting) function of the kidneys.
Interaction with other medicinal products and other types of interactions
The effect of Glutargin on insulin secretion is increased with the simultaneous use of aminophylline. Glutargin can enhance the effect of antiaggregatory agents (dipyridamole). Prevents and weakens neurotoxic phenomena that may occur with the use of isoniazid. Weakens the effect of vinblastine.