As a means of prevention and treatment in adults of secondary immunodeficiency conditions associated with radiation, chemical and infectious factors; to restore suppressed immune reactions and depressed state of the bone marrow hematopoiesis; to increase the body’s resistance to various pathological influences-infectious agents, chemical and / or physical factors (intoxication, radiation); as a hepatoprotective agent for chronic viral hepatitis B and C; to potentiate the therapeutic effects of antibacterial therapy for chronic obstructive pulmonary diseases;
Glutoxim №5 Storage
active substance: 1 ml of solution contains glutoxime (glutamyl-cysteinyl-glycine disodium) 10 mg or 30 mg;
Excipients: sodium acetate, dilute acetic acid, water for injections.
Glutoxim №5 Dosage form
Solution for injection.
Main physical and chemical properties: clear colorless or slightly colored liquid without smell or with a weak smell of acetic acid.
Glutoxim №5 Pharmacotherapeutic group
Other immunostimulants. Code ATX L0ZAH.
Glutoxime has an immunostimulatory, hemostimulating, toxic-modifying, hepatoprotective effect, inhibits the drug resistance of tumor cells to anthracycline antibiotics, alkylating agents; allows to overcome the drug resistance of Mycobacterium tuberculosis to isoniazid, associated with the genes katG (catalase peroxidase gene) and inhA (phenol-APB reductase gene). Glutoxime potentiates the effect of doxorubicin on tumor cells, chemotherapy (isoniazid, rifampicin, rifabutin, cycloserine, capreomycin, levofloxacin, cationic antimicrobial peptide catalcidin) on Mycobacterium tuberculosis.
Immunomodulatory effect of the drug Glutoxime is due to receptor-mediated effects on calcium-dependent signaling pathways of macrophages, which leads to increased:
Glutoxime belongs to a group of natural metabolites, which determines the peculiarities of its metabolism by existing cellular enzymatic systems. After intramuscular, intravenous or subcutaneous injection, the bioavailability exceeds 90%. There is a linear relationship between dose and concentration of the drug in blood plasma. The maximum concentration of the drug in blood plasma with intravenous administration is observed for 2-5 minutes, with intramuscular – for 7-10 minutes. As a natural product of peptide nature, Glutoxime is metabolized in organs and tissues of the body with elimination by the kidneys.
As a means of prevention and treatment in adults of secondary immunodeficiency conditions associated with radiation, chemical and infectious factors;
to restore suppressed immune reactions and suppressed bone marrow hematopoiesis;
to increase the body’s resistance to various pathological influences – infectious agents, chemical and / or physical factors (intoxication, radiation);
as a hepatoprotective agent in chronic viral hepatitis B and C;
to potentiate the therapeutic effects of antibacterial therapy of chronic obstructive pulmonary disease;
for the prevention of postoperative purulent complications;
The use of the drug is contraindicated in cases of individual hypersensitivity to the components of the drug.