edema in chronic heart failure; edema in chronic kidney failure; arterial hypertension; renal failure; acute renal failure, including during pregnancy or childbirth; edema of the lungs and brain; diuresis.
active substance: furosemide;
1 tablet contains 40 mg furosemide
excipients: lactose, corn starch, corn starch, talc, colloidal silicon dioxide, magnesium stearate.
Lazix Dosage form
Basic physical and chemical properties: white round tablets with the letter code “DLI” applied above and below the distribution line on one side.
Lazix Pharmacotherapeutic group
Highly active diuretics. Sulfonamide preparations. ATX code С03С А01.
Furosemide is a fast-acting loop diuretic, which leads to the establishment of a relatively strong and short-term diuretic effect. Furosemide blocks the Na + K + 2CI-cotransporter located in the basement membranes of the cells of the thick segment of the ascending part of Henle’s loop: the effectiveness of the saluretic action of furosemide, therefore, depends on whether the drug enters the tubules at the lumen by the anion transport mechanism. The diuretic effect occurs as a result of the reabsorption of sodium chloride in this segment of the Henle loop. As a result, fractional sodium excretion can reach 35% of sodium glomerular filtration rate. Secondary effects of increased sodium excretion are increased urinary excretion (due to osmotically bound water) and increased distal tubular potassium secretion. The excretion of calcium and magnesium ions also increases.
Furosemide is rapidly absorbed from the gastrointestinal tract. The maximum absorption time is from 1 to 1.5 hours. Drug absorption is indicative of significant individual variability.
The bioavailability of furosemide in healthy volunteers is approximately 50-70% for tablets. In patients, various factors affect the bioavailability of a drug, including existing diseases, bioavailability can decrease by up to 30% (for example, in nephrotic syndrome).
Possible effect of food while taking furosemide on the absorption of furosemide.
The volume of distribution of furosemide is from 0.1 to 0.2 liters per 1 kg of body weight. The volume of distribution may be higher depending on the disease.
Furosemide (more than 98%) forms strong compounds with blood plasma proteins, especially albumin.
Furosemide is excreted mainly as an unchanged drug by secretion into the proximal tubule.
The furosemide metabolite – glucuronide – makes up 10-20% of the substances contained in the urine. The residual dose is excreted in feces, probably by biliary secretion.
Furosemide passes into breast milk; penetrates the placental barrier and slowly enters the fetus. Furosemide is determined in the fetus or in newborns at the same concentrations as in the mother of the child.
Edema in chronic congestive heart failure (if treatment with diuretics is necessary).
Edema in chronic renal failure.
Acute renal failure, including in pregnant women or during childbirth.
Edema with nephrotic syndrome (if treatment with diuretics is necessary).
Edema in liver diseases (if necessary, to supplement treatment with aldosterone antagonists).
Sensitivity to furosemide or other components that make up the drug. Patients who are allergic to sulfonamides (eg, sulfonamide antibiotics or sulfonylureas) may have cross-sensitivity to furosemide.
Patients with hypovolemia or dehydration.
Patients with renal failure in the form of anuria who do not have a therapeutic response to furosemide
Patients with renal failure due to poisoning with nephrotoxic or hepatotoxic drugs.
Patients with severe hypokalemia.
Patients with severe hyponatremia.