Ischemic heart disease, including stable stress angina; unstable angina (progressive angina, resting angina); vasospastic angina (variant angina, Prinzmetal angina); postinfarction angina in patients without heart failure, unless b-blockers are indicated. Arrhythmias: paroxysmal supraventricular tachycardia; atrial flutter / flicker with rapid atrioventricular conduction (except for wolf-Parkinson-white syndrome (WPW). Arterial hypertension
active substance: verapamil;
1 tablet contains verapamil hydrochloride 40 mg or 80 mg;
80 mg tablets: corn starch, lactose, potato starch, croscarmellose sodium, talc, colloidal silicon dioxide, magnesium stearate, povidone, sodium carmellose, sucrose, polysorbate 80, calcium carbonate, quinoline yellow dye (E 104), titanium dioxide (E 171), capol 600.
Lecoptin Dosage form
Basic physical and chemical properties: yellow, round, biconvex film-coated tablets.
Lecoptin Pharmacotherapeutic group
Selective calcium channel blockers with direct effects on the heart. Phenylalkylamine derivatives. ATX code С08D A01.
Verapamil blocks the transmembrane flow of calcium ions into cardiomyocytes and vascular smooth muscle cells. It directly reduces myocardial oxygen demand by affecting the energy-consuming metabolic processes in myocardial cells and indirectly affects the reduction of afterload. By blocking the calcium channels of the smooth muscle cells of the coronary arteries, blood flow to the myocardium increases even in the post-stenotic areas and the spasm of the coronary arteries is eliminated. The antihypertensive efficacy of verapamil is due to a decrease in peripheral vascular resistance without an increase in heart rate as a reflex response.
No undesirable changes in the physiological values of blood pressure are observed. Verapamil has a pronounced antiarrhythmic effect, especially in supraventricular arrhythmias. It delays the conduction of the impulse in the atrioventricular node, as a result of which, depending on the type of arrhythmia, the sinus rhythm is restored and / or the ventricular rate is normalized. The normal heart rate level does not change or decreases slightly.
Verapamil hydrochloride is a racemic mixture consisting of equal parts of the R-enantiomer and the S-enantiomer. Verapamil is actively metabolized. Norverapamil is one of the 12 metabolites that are detected in urine, has 10-20% of the pharmacological activity of verapamil and accounts for 6% of the excreted drug. Equilibrium plasma concentrations of norverapamil and verapamil are the same. Equilibrium concentration is achieved 3-4 days after repeated administration of the drug once a day.