Poisoning by a pale toadstool.
Legalon-140 №60 Composition
One capsule contains:
Legalon-140 №60 Active substance:
milk thistle fruit dry extract (36-44: 1) – 173.0-186.7 mg, equivalent to 140 mg of silymarin (DNPH), equivalent to 108.2 mg of silymarin (HPLC / Ger.F.) calculated on silybinin.
Excipients: polysorbate 80, povidone, mannitol, sodium carboxymethyl starch (type A), magnesium stearate.
The shell is a hard gelatin capsule, size “1”, which includes: gelatin, iron dye red oxide (E172), titanium dioxide (E171), sodium lauryl sulfate, iron dye black oxide (E172).
Legalon-140 №60 pharmachologic effect
Milk thistle fruit dry extract is standardized for silymarin content.
Therapeutic action of silymarin:
Detoxification. The antitoxic effect of silymarin has been identified in studies on various models of liver damage, for example, the pale grebe toxin phalloidin and alpha-amanitin, lanthanides, carbon tetrachloride, galactosamine, thioacetamide and the hepotoxic FV3 virus.
Cytoprotective. Silymarin inhibits the penetration of some hepatotoxic substances into the cell (the poison of the pale toadstool).
Antioxidant. Due to the ability of silymarin to bind free radicals, it has antioxidant activity. The pathophysiological process of lipid peroxidation, which is responsible for the destruction of cell membranes, is interrupted or prevented. Silymarin acts not only as an antioxidant – reducing the generation of free radicals, but also as a means of stimulating the regeneration of the glutathione system, one of the most important protective systems of the liver.
Regenerative. Membrane stabilizing. Silymarin stimulates the synthesis of proteins and phospholipids. Cell membranes are stabilized. Own proteins and phospholipids restore the damaged structures of the hepatocyte. The regenerative ability is improved and the regeneration of liver cells is accelerated. This effect is not observed in intact cells.
Hypocholesterolemic. Silymarin normalizes hyperlipidemia, lowers blood plasma cholesterol and low density lipoprotein (LDL) levels.
Antifibrous. Silymarin inhibits collagenase and elastase in the liver, helping to reduce the degree of fibrosis.
Anti-inflammatory. A key feature of silymarin / silibinin is the ability to block the 5-lipoxygenase pathway and inhibit the formation of leukotriene.
Legalon-140 №60 Pharmacokinetics
The main component of silymarin is silibinin. When taken orally, silibinin quickly dissolves and enters the intestine, then through the portal vein system, 85% of it enters the liver and is selectively distributed in hepatocytes, where it is metabolized by conjugation. Up to 80% of the active substance during the first passage through the liver is excreted in the bile in combination with glucuronides and sulfates. Due to deconjugation in the intestine, up to 40% of silibinin released with bile is reabsorbed and enters into enterohepatic circulation, the elimination period is 6.3 hours. Bioavailability of Legalon® 140 is 85%.
When taking milk thistle fruit extract in therapeutic doses (140 mg of silymarin 3 times a day), the level of silibinin in bile is the same after taking repeated doses and after taking a single dose. The results showed that silibinin does not accumulate in the body.
After repeated administration of silymarin, 140 mg orally 3 times a day, a stable level of excretion with bile is achieved.
In the complex therapy of chronic inflammatory liver diseases, liver cirrhosis and toxic liver damage (caused by substances toxic to the liver).