Poisoning by a pale toadstool.
Legalon-70 capsules Composition of the medicinal product
active ingredient: 1 capsule contains 86.5 mg – 93.3 mg of dry extract from the fruit of milk thistle (Silybum marianum) [36-44: 1], corresponds to 70 mg of silymarin (DNPH), or 54.1 mg of silymarin (TOP / DAB) in terms of silibinin (solvent – ethyl acetate)
excipients: polysorbate 80, povidone, E421 lures, sodium starch (type A), magnesium stearate, iron oxide red E172, iron oxide black E172, titanium dioxide E 171, gelatin, sodium lauryl sulfate.
Legalon-70 capsules Dosage form
Capsules. Size 2 brown hard gelatin capsule containing yellow powder.
Legalon-70 capsules Pharmacological group
Drugs used to treat liver diseases. Hepatotropic drugs. ATC code A05B A03.
The ability of silymarin to bind free radicals provides its antioxidant activity. Thus, the pathophysiological process of lipid peroxidation, which is responsible for the destruction of cell membranes, is interrupted or prevented. In damaged hepatocytes, silymarin stimulates protein synthesis and normalizes the metabolism of phospholipids, as a result of which silymarin stabilizes cell membranes and limits or prevents the loss of soluble components (in particular transaminases) of liver cells. Silymarin inhibits the penetration of some hepatotoxic substances into the cell (the poison of the pale toadstool). Silymarin enhances protein synthesis by specifically stimulating RNA polymerase A, an enzyme found in the nucleus. This leads to increased production of ribosomal RNAs, and therefore to stimulation of the synthesis of structural and functional proteins (enzymes). As a result, the regenerative ability is improved and the regeneration of liver cells is accelerated.
Absorption – low and slow (half-absorption period – 2.2 hours), metabolized in the liver by conjugation, half-life – 6.3 hours. It is excreted mainly in the bile in the form of glucuronides and sulfates. Does not accumulate in the body. Intestinal-hepatic circulation is noted.
Legalon-70 capsules Indications
Toxic liver damage: for the maintenance treatment of patients with chronic inflammatory liver disease or liver cirrhosis.
If jaundice develops, it is necessary to consult a doctor for correction of therapy.