Assign to adults for the treatment of infections caused by microorganisms sensitive to the drug: community-acquired pneumonia; complicated skin and soft tissue infections; (For the above-mentioned infections, Levofloxacin should only be used when the use of other antibacterial agents that are usually recommended for the initial treatment of these infections is impractical or impossible); pyelonephritis, complicated urinary tract infections; chronic bacterial prostatitis.
active substance: levofloxacin;
1 tablet of Levofloxacin-Teva, 250 mg, contains 256.23 mg of levofloxacin hemihydrate, which is equivalent to 250 mg of levofloxacin;
1 500 mg Levofloxacin-Teva tablet contains 512.46 mg of levofloxacin hemihydrate, which is equivalent to 500 mg of levofloxacin;
excipients: sodium stearyl fumarate, crospovidone, colloidal silicon dioxide, copolyvidone, microcrystalline cellulose, Opadry II pink shell 31K34554.
Levofloxacin-TEVA Dosage form
Basic physical and chemical properties: pink, oval, biconvex, 6 x 13 mm or 8 x 16 mm, film-coated, with a notch on one side and on the sides; with “L” engraved on the risk-free side.
Levofloxacin-TEVA Pharmacotherapeutic group
Antibacterial agents of the quinolone group. Fluoroquinolones.
ATX code J01M A12.
Levofloxacin is characterized by a broad spectrum of antibacterial action. The bactericidal effect is provided due to the inhibition by levofloxacin of the bacterial enzyme DNA gyrase, which belongs to type II topoisomerases. The result of such oppression is the impossibility of the transition of bacterial DNA from a state of relaxation to a twisting state, which, in turn, makes it impossible for further division (reproduction) of bacterial cells. The spectrum of activity of levofloxacin includes gram-positive, gram-negative bacteria together with non-fermenting bacteria.
Usually sensitive species
Gram-positive aerobes: Bacillus anthracis, Staphylococcus aureus methicilinchutlivi, Staphylococcus saprophyticus, Streptococci, group C and G, Streptococcus agalactiae, Streptococcus pneumonia, Streptococcus pyogenes.
Gram-negative aerobes: Eikenella corrodens, Haemophilus influenzae, Haemophilus parainfluenzae,
Klebsiella oxytoca, Moraxella catarrhalis, Pasteurella multocida, Proteus vulgaris, Providencia rettgeri.
Others: Chlamydophila pneumonia, Chlamydophila psittaci, Chlamydia trachomatis, Legionella pneumophila, Mycoplasma pneumonia, Mycoplasma hominis, Ureaplasma urealyticum.
Species with possible acquired resistance
Gram-positive aerobes: Enterococcus faecalis, Staphylococcus aureus methicillinchutlivi, coagulase-negative Staphylococcus spp.
Gram-negative aerobes: Acinetobacter baumannii, Citrobacter freundii, Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Morganella morganii, Proteus mirabilis, Providencia stuartii, Pseudomonas aeruginosa, Serratia marcescece.
Anaerobes: Bacteroides fragilis.
Naturally resistant strains