Tablets: infectious and inflammatory diseases caused by microorganisms sensitive to the drug: typhoid fever, paratyphoid, yersiniosis, brucellosis, shigellosis, salmonellosis, tularemia, rickettsiosis, chlamydia, purulent peritonitis, bacterial meningitis, biliary tract infections. Drops: conjunctivitis, keratitis, blepharitis caused by microorganisms sensitive to the drug.
Levomycetin powder Composition
active substance: 1 bottle contains sterile chloramphenicol sodium succinate in terms of chloramphenicol 0.5 g or 1.0 g.
Levomycetin powder Dosage form.
Powder for solution for injection.
Basic physical and chemical properties: powder, white or white with a yellowish tinge. Hygroscopic.
Levomycetin powder Pharmacotherapeutic group.
Antimicrobial agents for systemic use. Amphenicol.
ATX code J01B A01.
Levomycetin powder Pharmacological properties
Broad-spectrum antibiotic. Effective against many gram-positive (staphylococci, streptococci, pneumococci, enterococci) and gram-negative bacteria: colibacillus and hemophilus influenzae, salmonella, shigella, klebsiella, serration, yersinia, proteus, gonococci, meningococci, anketeaerobes, rhykydylamines (causative agents of trachoma, psittacosis, inguinal lymphogranulomatosis and others); acts on strains of bacteria resistant to penicillin, streptomycin, sulfonamides; weakly active against acid-fast bacteria, Pseudomonas aeruginosa, clostridia and protozoa. In usual doses it acts bacteriostatically. Inhibits peptidyltransferase and disrupts protein synthesis in a bacterial cell.
With intramuscular and intravenous administration, a high concentration of the drug in the blood plasma is quickly achieved (5-10 minutes after intravenous administration, 30-45 minutes after intramuscular administration). The maximum concentration in the blood is reached after 1 hour and remains in effective concentrations in the blood plasma for 8-12 hours. A significant part (60-80%) binds to plasma albumin. Easily penetrates into organs and body fluids, through the blood-brain barrier, through the placenta, into breast milk.
It is excreted mainly by the kidneys in the form of inactive metabolites, partly with bile.
Treatment of infections caused by microorganisms sensitive to chloramphenicol (typhoid fever, paratyphoid fever, generalized forms of salmonellosis, dysentery, brucellosis, tularemia, meningitis, typhus and other rickettsioses, trachoma). Infectious processes caused by pathogens sensitive to the action of chloramphenicol in case of ineffectiveness of other chemotherapeutic drugs or when their use is impossible.
Hypersensitivity to chloramphenicol, other amphenicol, inhibition of hematopoiesis, blood diseases; skin diseases (psoriasis, eczema, fungal infections); severe liver and / or kidney dysfunctions; deficiency of the enzyme glucose-6-phosphate dehydrogenase; porphyria.
Levomycetin should not be prescribed for acute respiratory diseases, sore throat, as well as for the prevention of bacterial infection.