Tablets: infectious and inflammatory diseases caused by microorganisms sensitive to the drug: typhoid fever, paratyphoid, yersiniosis, brucellosis, shigellosis, salmonellosis, tularemia, rickettsiosis, chlamydia, purulent peritonitis, bacterial meningitis, biliary tract infections. Drops: conjunctivitis, keratitis, blepharitis caused by microorganisms sensitive to the drug.
Levomycetin alcoholic Composition
active substance: chloramphenicol;
1 ml of the drug contains 2.5 mg of chloramphenicol;
excipients: ethanol 70%.
Levomycetin alcoholic Dosage form
Cutaneous solution, alcohol 0.25%.
Basic physical and chemical properties: transparent, colorless liquid with an alcoholic odor.
Levomycetin alcoholic Pharmacotherapeutic group
Topical antibiotics. ATX code D06A X02.
Levomycetin alcoholic Pharmacodynamics
When applied topically, the drug has an antimicrobial effect against most gram-positive and gram-negative bacteria. Affects pathogens resistant to antibiotics of the group of penicillin, streptomycin, sulfonamides. Resistance to chloramphenicol itself develops slowly. The drug has a bacteriostatic effect; being fat-soluble, chloramphenicol penetrates the bacterial cell membrane and reversibly binds to the 50S subunit of bacterial ribosomes, in which the movement of amino acids to peptide chains is delayed, grow, as a result of which the formation of peptide bonds and further protein synthesis are disrupted.
When applied externally, the drug does not penetrate well through intact skin and mucous membranes, therefore the resorptive effect is weak. The bacteriostatic effect when applied to the surface depends on the size of the affected area, the amount of manure, mechanical obstacles. On average, the antimicrobial effect lasts for 6-12 hours, after which the application of the drug should be repeated.
It is used externally for burns, cuts, skin cracks, otitis media and inflammatory diseases complicated by purulent pathology.
Hypersensitivity to the components of the drug, deficiency of the enzyme glucose-6-phosphate dehydrogenase, acute intermittent porphyria, skin diseases (psoriasis, eczema, fungal infections).
Interaction with other medicinal products and other types of interactions
Simultaneous use with drugs that inhibit hematopoiesis (sulfonamides, cytostatics, pyrazoline derivatives) is undesirable.
For severe infections of the skin or ears, chloramphenicol should be applied externally after consultation with a doctor in complex therapy together with antibacterial agents of systemic action.
The ability to influence the reaction rate when driving or operating machinery
There is no evidence that the drug can adversely affect the reaction rate when driving or operating other mechanisms.
Use during pregnancy or lactation
The drug is contraindicated during pregnancy and lactation.
Method of administration and dosage
For external use only. Lubricate the affected skin surfaces (can be used under an occlusive dressing). The duration of treatment depends on the nature of the pathological process, its severity, and the achieved effect. With purulent otitis media, the drug is instilled into the external auditory canal (2-3 drops). The procedure is repeated 1-2 times a day, and with significant secretions that wash off the applied solution – up to 3-4 times a day.
Not prescribed for children under the age of 1 year.
In case of an overdose of the drug, irritation of the skin and mucous membranes, local allergic reactions in the form of rashes, itching, redness and swelling of tissues, and increased manifestations of other adverse reactions are possible.
From the immune system: allergic reactions, including skin rashes, itching, dermatitis, burning sensation, hyperemia, angioedema, urticaria. If such reactions develop, the use of the drug should be discontinued.