Limzer capsules №30

$28.00

Functional dyspepsia, reflux esophagitis, delayed evacuation of the contents of the stomach and gastroparesis.

Category:

Description

Limzer capsules Composition
1 capsule contains:

Limzer capsules omeprazole 20 mg,
domperidone 30 mg
excipients: neutral micropellets (sucrose, corn starch, povidone, hypromellose), hypromellose, talc, methacrylate copolymer dispersion, sodium hydroxide, colloidal silicon dioxide, ethyl cellulose, titanium dioxide (E 171), triacetin, glycerin polysobearate, magnesium hypromellose phthalate, dibutyl sebacate, iron oxide yellow (E 172), iron oxide red (E172)

capsule shell: gelatin, methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), Ponceau 4 R (E 124), sunset yellow FCF (E 110), titanium dioxide (E 171)

Limzer capsules Release form
Capsules (10 or 14 capsules in a strip. 1, 3 or 10 strips in a carton box).

Basic physical and chemical properties
Hard gelatin capsules of size “3” with an orange body and a red lid, containing a mixture of white or almost white pellets and brown or yellowish-brown pellets, have a spherical or oval shape.

Limzer capsules pharmachologic effect
Pharmacodynamics
Combined drug, the action of which is due to the components that make up its composition.

Omeprazole belongs to antiulcer drugs that inhibit the basal and stimulated secretion of hydrochloric acid in the parietal cells of the stomach due to a specific effect on H + -K + – ATP-ase (proton pump). The antisecretory effect after taking omeprazole develops very quickly during the first hour and lasts for a day. Omeprazole, due to its high lipophilicity, easily penetrates into the parietal cells of the stomach, concentrates in them and has a cytoprotective effect. The inhibitory effect increases in the first 4 days of administration. Omeprazole does not affect gastrointestinal motility.

Domperidone blocks peripheral dopamine receptors, eliminates the inhibitory effect of dopamine on the motor function of the digestive tract and increases the evacuation and motor activity of the stomach. Has antiemetic effect, soothes hiccups and eliminates nausea. Poorly penetrates the blood-brain barrier, practically does not affect dopamine receptors in the brain.

Limzer capsules Pharmacokinetics
Has not been studied.

Limzer capsules Indications for use
Treatment of gastric ulcer and duodenal ulcer in the absence of Helicobacter pylori, delayed evacuation of stomach contents, Gastroparesis, reflux esophagitis, functional dyspepsia.

Limzer capsules Contraindications
Limser is contraindicated:

patients with established hypersensitivity to the drug or to excipients;
patients with prolactin-secretory pituitary tumor (prolactinoma)
patients with severe or moderate impairment of liver and / or kidney function (see section “Peculiarities of use”);
patients with a known lengthening of cardiac conduction intervals, in particular QTc, patients with significant electrolyte imbalance or with underlying heart disease, such as congestive heart failure (see section “Peculiarities of use”);
patients with liver failure
if stimulation of the motor function of the stomach can be dangerous, for example, with gastrointestinal bleeding, mechanical obstruction or perforation;
concomitant use of ketoconazole, erythromycin or other potent CYP3A4 inhibitors is contraindicated;
the simultaneous use of drugs that prolong the QT interval, such as fluconazole, erythromycin, itraconazole, oral ketoconazole, Posaconazole, ritonavir, saquinavir, telaprevir, voriconazole, clarithromycin, amiodarone, telithromycin, etc. drugs and other types of interactions “).