Lirica 300 capsules 300 mg. №21


Lirica is intended to relieve pain in fibromyalgia and neuropathic pain.
In addition, the drug is used to treat patients with anxiety disorders, epileptic seizures. For the latter, taking the drug is indicated both for the permanent treatment of epilepsy and for partial seizures.



Lirica 300 composition
active substance: pregabalin;
1 capsule contains 300 mg of pregabalin;
excipients: lactose monohydrate; corn starch; talc; capsule shell: gelatin, water, titanium dioxide (E 171), sodium lauryl sulfate, colloidal anhydrous silica, iron oxide red (E 172); inks: shellac, black iron oxide (E 172), propylene glycol, potassium hydroxide.

Dosage form

Pharmacological properties
Anticonvulsant and antiepileptic drug. The active component of the drug, pregabalin, inhibits the movement of calcium into neuronal cells in response to an action potential. The substance is characterized by a high degree of affinity for the alpha-2-delta protein found in the tissues of the central nervous system. The use of the drug leads to a decrease in the release of pain neurotransmitters into the synaptic cleft when neurons are excited. As a result of such changes under the action of the drug, impulse conduction is selectively suppressed. But only in pathological conditions Lirica has such an effect.
The Lirica 300 have analgesic properties for painful sensations of non-neuropathic and postoperative origin.
Does not provoke cancer.
The drug is well absorbed and begins to act within an hour after administration. The drug is best taken on an empty stomach, since plasma concentrations of the drug are significantly reduced when taken simultaneously with food.

Indications for use
The Lirica 300 are designed to relieve pain in fibromyalgia and neuropathic pain.
In addition, the drug is used to treat patients with anxiety disorders, epileptic seizures. For the latter, taking the drug is indicated both for the permanent treatment of epilepsy and for partial seizures.

Lirica is contraindicated in case of individual intolerance or hypersensitivity to any of the ingredients of the drug.
When prescribing the drug, special attention should be paid to pregnant and lactating women, as well as patients with renal dysfunction.

Not used to treat children under 12 years of age.

Pregnancy and breastfeeding period
There is not enough data on the use of Lirica in pregnant women. Therefore, strict medical supervision is recommended during drug therapy during pregnancy, before carefully weighing the risks and benefits.
For women of reproductive age, it is best to exclude pregnancy and use reliable contraceptives.
Breastfeeding and the course of drug therapy are incompatible.

Mode of application
Lirica 300 capsules are taken whole, orally. Tablets are not recommended to be chewed or crushed.
Lirica are taken regardless of food, but more effective on an empty stomach.
The dosage is selected individually by the attending physician, which depends on the characteristics of the patient, the nature of the disease and the course of the disease.
The average recommended dose is 75 mg twice a day for neuropathic pain, epilepsy. The dose can be increased to 150 mg as needed, also twice a day.
If the patient is not sensitive to the action of the drug or he has a severe case, then the initial dosage is 150 mg of the drug, which is then doubled. The interval between each dose increase should be at least a week.
The maximum allowable daily dose is 600 mg.
The duration of treatment depends on the effectiveness of the treatment. It is impossible to abruptly cancel the drug – the dosage is gradually reduced, bringing it to zero.
For patients with problems in the renal system, the dosage is calculated based on the level of creatinine clearance. The lower the ratio ml / min, the lower the daily and initial doses of the drug.
When prescribing a drug, older people need to check the functioning of the kidneys to determine the dosage. Under normal conditions, the dose is the same as for others.

Cases of drug overdose have not been described. In extreme cases, side effects may increase.

Adverse reactions
Despite the rather good reviews and patient tolerance of Lyrica, in some cases the following side effects are noted:

  • eating disorders (both anorexia and bulimia), dry mouth, nausea, upset stools, the development of pancreatitis, the appearance of flatulence.
  • tachycardia, neutropenia, hyperemia and hot flushes, atrioventricular block of the first degree, changes in blood pressure.
  • dizziness, headaches, drowsiness, ataxia, decreased attention, lack of coordination, euphoria, increased irritability, confusion. In addition, partial memory loss, impaired speech function, insomnia, the development of depression, causeless anxiety, anxiety are possible.
  • disturbances of visual functions, increased lacrimation, dry eyes.
  • cough, runny nose, snoring, respiratory failure.
  • cramps, pain in the musculoskeletal system, joints, muscles.
  • renal failure, urinary incontinence, impaired reproductive and sexual functions.
  • allergic reactions.
  • increased sweating, discharge from the chest, soreness and enlargement of the mammary glands.

Storage conditions
The Lirica 300 are stored between 15 and 25 C, in a dark, dry place, away from children.