Lisinoprazid tablets 10 mg/12.5 mg. №30


This drug Lisinoprazid tablets is used for the treatment of mild and moderate arterial hypertension, the body of which responds positively to the intake of these drugs and in which it stabilizes due to the intake of these components.



Lisinoprazid tablets composition
active substances: 1 tablet contains lisinopril dihydrate in terms of 100% substance 10 mg and hydrochlorothiazide 12.5 mg;
Excipients: mannitol (E 421), magnesium stearate, calcium hydrogen phosphate, corn starch, pregelatinized corn starch.

Dosage form

Pharmacological properties
This drug Lisinoprazid tablets belongs to combined drugs – inhibitors of angiotensin-converting enzymes and diuretics.
The effect of the drug is explained by the properties of its main components – lisinopril, an ACE inhibitor and hydrochlorothiazide, a thiazide diuretic. These substances complement each other’s effectiveness, enhancing the hypotensive effect.
Lisinopril is a peptidyl dipeptidase inhibitor that suppresses the ACE enzyme that promotes the conversion of angiotensin I into the angiotensin II peptide, which constricts blood vessels. The latter causes stimulation of the secretion of aldosterone by the adrenal glands. As a result of metabolic processes, it leads to an increase in serum potassium, a decrease in blood pressure, including in patients with low renin.
Hydrochlorothiazide is a diuretic that causes the reabsorption of electrolytes in the kidneys, increasing the excretion of sodium and chloride, and potassium and bicarbonate can be lost. By itself, without causing a decrease in pressure, it nevertheless contributes to this process used in combination.

This drug Lisinoprazid tablets is used for the treatment of mild and moderate arterial hypertension, the body of which responds positively to the intake of these drugs and in which it stabilizes due to the intake of these components.

Not applicable if the patient has hypersensitivity (allergy) to one of the components that make up the drug.
Also, use is contraindicated for:

  • anuria;
  • hemodynamically significant aortic or mitral stenosis, hypertrophic cardiomyopathy with outflow tract obstruction;
  • unstable hemodynamics after acute myocardial infarction, cardiogenic shock;
  • renal artery stenosis (bilateral or unilateral);
  • primary hyperaldosteronism;
  • hypokalemia.

This drug is contraindicated for use in pediatrics.

Application during pregnancy and lactation
Treatment of pregnant women is contraindicated, since there is no guarantee of complete safety of its use for both the woman and the fetus.
During treatment, lactation (breastfeeding) should be suspended.

Method of administration and dosage
Usually, 1 tablet of the drug Lisinoprazid tablets is prescribed in a dosage of 10 mg of lisinopril 1 time per day, taken at the same time of the day.
If the application for 2-4 weeks does not produce an effect, the dosage is increased to 2 tablets per day.
If further treatment is ineffective, the patient is transferred to an increased dosage of the drug of 20 mg 1 or 2 times a day (according to indications).
Taking diuretics is canceled 2-3 days before taking the drug.
The maximum dosage of lisinopril per day is 80 mg.
The drug is ineffective for impaired renal function with a creatinine clearance value of 30 ml / min or less (moderate / severe renal failure).
Elderly patients or patients with liver disease do not need a dosage adjustment.

Overdose symptoms are:

  • arterial hypotension, circulatory shock, electrolyte imbalance;
  • renal failure, hyperventilation;
  • tachycardia, bradycardia, arrhythmia;
  • dizziness, anxiety, cough.
  • a decrease in electrolytes (hypokalemia, hypochloremia, hyponatremia) with an overdose of hydrochlorothiazide and dehydration as a result of excessive diuresis;

Treatment is symptomatic. It is necessary to control the level of electrolytes in the blood.
Hemodialysis is recommended.

Side effects
In some cases, there are side effects such as:

  • dizziness, headache, loss of consciousness;
  • orthostatic hypotension;
  • cough, rhinitis, chest pain, diarrhea, nausea, rash, itching;
  • mood changes, depression;
  • paresthesia, vertigo, taste disturbances, insomnia;
  • increased levels of liver enzymes and bilirubin;
  • fatigue, asthenia, impotence;
  • increased blood urea, increased serum creatinine, hyperkalemia.
  • myocardial infarction or stroke as a result of excessive hypotension in high-risk patients, palpitations, tachycardia.

If you have any unusual side effects as a result of taking this drug, you should consult your doctor about possible changes in the treatment regimen.

Storage conditions and periods
The shelf life of the drug is no more than 3 years from the production date indicated on the package.
This medicinal product should be stored in a dry place out of the reach of children, at a temperature not exceeding 25 ° C.