Loratadin tablets (loratadine) 0.01g. №20


Symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.



Loratadin tablets composition
active substance: loratadine;
1 tablet contains loratadine 10 mg;
excipients: lactose, monohydrate; potato starch; calcium stearate.

Dosage form

Pharmacological properties
This drug Loratadin tablets belongs to the group of antihistamines used systemically in the treatment of epilepsy.
The active component of this drug, loratadine, is a tricyclic selective blocker of peripheral histamine receptors (H1).
If loratadine is used in a dose not exceeding the recommended dose, then the drug does not produce a sedative or anticholinergic effect, which can have a noticeable or clinically significant effect on the body.
Even with prolonged use, patients do not show clinically significant changes in the indicators of the main body functions. Data from laboratory, physical studies, as well as electrocardiograms do not go beyond the norm.
Does not affect histamine H2 receptors. Does not have the ability to block the seizure of norepinephrine.
Does not affect the work of the cardiovascular system, does not change the activity of the implanted pacemaker.
When taken orally, due to metabolic processes, it is converted into desloratadine, effectively binding to blood proteins.
The bioavailability of the drug is proportional to the dose taken.

This drug Loratadin tablets is used in the symptomatic treatment of allergic rhinitis and / or chronic idiopathic urticaria.

Not applicable if the patient has hypersensitivity (allergy) to one of the components that make up the drug.
Concomitant use with CYP3A4 or CYP2D6 inhibitors can lead to an increase in loratadine levels, causing increased side effects.
Alcoholic drinks are acceptable.
Should not be taken simultaneously with other H-1 receptor blockers, barbiturates, benzodiazepines, opioid receptor agonists, antipsychotics, tricyclic antidepressants, anxiolytics, sedatives and hypnotics.
It is used with caution in the treatment of patients who have been diagnosed with severe hepatic failure.
Reception by a patient suffering from lactose intolerance is contraindicated.
Do not use for 48 hours before testing for allergy tests.

In pediatrics, it is used from 2 years of age, subject to a body weight of at least 30 kg.

Application during pregnancy and lactation
It is not used to treat pregnant women.
If there is a need to take this drug, then during treatment, lactation (breastfeeding) should be suspended.

Method of administration and dosage
Loratadin tablets is taken orally, with or without food.
Adults and children weighing more than 30 kg take 1 tablet (10 mg loratadine) 1 time per day.
Elderly patients and patients with renal insufficiency do not need dosage adjustment.
Loratadine in tablet form is not recommended for children weighing less than 30 kg. It is advisable to use the drug in the form of a syrup.

In case of an overdose, side effects may occur in the form of:

  • drowsiness;
  • tachycardia;
  • headache.

Hemodialysis is ineffective.
It is necessary to wash the stomach, take sorbents, establish monitoring of the patient’s condition, and, if necessary, carry out a complex of standard supportive symptomatic therapy.

Side effects
Therapy with this drug can cause side reactions in the form of:

  • headache, nervousness, fatigue, increased appetite, insomnia;
  • vomiting, nausea, dry mouth, gastritis;
  • sedative effects (in children);
  • anaphylactic shock;
  • dizziness;
  • tachycardia, arterial hypertension, arterial hypotension, cardiac arrhythmias;
  • dryness of the mucous membranes in the nose, sinusitis, cough;
  • itching, allergic urticaria;
  • violations of the liver;
  • skin rash, alopecia;
  • increased fatigue;
  • back pain, chest pain, fever.

In case of undescribed or unusual side effects, you should consult a doctor for a possible adjustment of the treatment process.

Storage conditions and periods
The shelf life of the drug is no more than 2 years from the production date indicated on the package.
Store in a dry place out of the reach of children, at a temperature not exceeding 25 ° C.