Acute and chronic coronary heart disease. Prevention of repeated thrombosis. Primary prevention of thrombosis, cardiovascular diseases, such as acute coronary syndrome.
active substance: 1 tablet contains acetylsalicylic acid 75 mg;
excipients: magnesium hydroxide; corn starch; microcrystalline cellulose; potato starch; magnesium stearate;
shell: mixture for film coating Oradry II White (hypromellose (hydroxypropylmethylcellulose); lactose, monohydrate; polyethylene glycol (macrogol); titanium dioxide (E 171); triacetin).
Combined drug Magnicor, with acetylsalicylic acid and magnesium hydroxide included in its composition, help prolong bleeding, which is used in medicine to treat diseases of the cardiovascular system.
Magnicor is prescribed for chronic and acute ischemic heart disease, including:
- unstable angina;
- acute myocardial infarction.
It is also prescribed as a prophylactic agent in order to prevent the formation of blood clots in acute coronary syndrome.
It is recommended to use it for obesity, diabetes mellitus, hypercholesterolemia, as well as for patients under the age of 55 who have already suffered myocardial infarction by this age.
Acetylsalicylic acid, which is part of its drug, has anti-inflammatory, antipyretic, analgesic and antiaggregative effects.
The main pharmacological effect of the substance is the ability to inhibit prostaglandin and thromboxane synthesis. The anti-inflammatory effect is due to the effect on reducing the intensity of blood flow. Has the ability to prolong bleeding time.
As for the action of magnesium hydroxide, this substance acts as an antacid, neutralizing the secretion of hydrochloric acid by the stomach, thus protecting the intestinal walls from irritation due to the action of acetylsalicylic acid.
Do not use if the patient has individual hypersensitivity to aspirin (acetylsalicylic acid). Not prescribed for peptic ulcer disease in the acute stage, increased risk of bleeding (anemia, thrombocytopenia, vitamin K deficiency).
It should not be used in case of heart failure, as well as renal and hepatic failure, if they are severe.
Not used to treat children under 12 years of age.
Application during pregnancy and lactation
Prescribed only if the positive effect exceeds the risks of fetal development, and only in the period from 1 to 6 months of pregnancy. In this case, the dose should be minimal – up to 100 milligrams per day, under the strict supervision of a physician.
Method of administration and dosage
Take the whole Magnicor tablet, usually at a dosage of 75-150 milligrams per day. If necessary, chewing the tablet is permissible, you can also grind or break it.
If the drug is prescribed for acute or chronic heart disease, let’s say taking 75-150 milligrams. In case of angina pectoris or acute myocardial infarction, the dose may be increased to 450 mg per day.
For the prevention of thrombus formation, disorders of the cardiovascular system, 150-75 milligrams of the drug (2-1 tablets) are prescribed.
Overdose is possible if you take a dose of more than 150 milligrams per 1 kg of body weight per day for a long time. The body can react with dizziness, deafness, tinnitus, vasodilation, sweating, nausea, vomiting, headache.
In severe poisoning, metabolic acidosis, ketosis, and hyperventilation of the lungs may occur. A severe course can cause depression of the central nervous system, coma, collapse and respiratory arrest.
The development of liver failure can be a frequent occurrence.
In case of an overdose, the stomach should be flushed, enterosorbents should be taken, it is important to restore the water-electrolyte balance in order to avoid the development of acidosis, dehydration, and the risk of hyperkalemia.
Shown hemodialysis, alkaline diuresis.
Excessive bleeding, anemia, rarely – neutropenia, thrombocytopenia, agranulocytosis, eosonophilia, aplastic anemia are possible.
Sleep disorder, headaches, ringing or tinnitus may occur. People with bronchial asthma may experience bronchospasm.
Possible disorders of the gastrointestinal tract, allergic skin reactions, allergic rhinitis (runny nose). In isolated cases, anaphylaxis was observed.
Storage conditions and periods
Stored for up to 4 years at temperatures up to 25 ° C.