Inflammation of the eye tissues in which the use of corticosteroids is indicated and there is a superficial bacterial infection or risk of its development (inflammation of the bulbar conjunctiva and the conjunctiva of the eyelids, the cornea and the anterior segment of the eyeball, chronic uveitis of the anterior segment and corneal damage caused by chemical, radiation or heat burns or foreign bodies).
active substances: dexamethasone, neomycin sulfate, polymyxin B sulfate;
1 ml of suspension contains dexamethasone 1 mg, neomycin sulfate 3500 IU, polymyxin B sulfate 6000 IU;
Excipients: polysorbate 20, sodium chloride, concentrated hydrochloric acid and / or sodium hydroxide (for pH adjustment), hypromellose, benzalkonium chloride, purified water.
It is a combined anti-inflammatory and antibacterial agent for topical use in ophthalmology. Contains an antibiotic aminoglycoside, which penetrates the bacterial cell membrane, binds to specific receptors on the 30S ribosome subunit and disrupts the process of protein synthesis, exerting a bacteriostatic effect (stops the growth and reproduction of bacteria). At higher concentrations, it damages the cytoplasmic membranes of microbial cells, causing their rapid death (bactericidal effect). Polymyxin B is an antibiotic of a polypeptide structure that binds to phospholipids of cell membranes, destroying them. Dexamethasone is a glucocorticoid agent that has a pronounced antiallergic, anti-inflammatory, desensitizing effect.
Maxitrol is used for infectious and inflammatory diseases of the eyes (for inflammation of the eyelid conjunctiva, bulbar conjunctiva, cornea, anterior segment of the eyeball, for chronic uveitis, corneal damage caused by radiation, chemical, thermal burns, foreign bodies).
- with viral diseases of the cornea, conjunctiva (including chickenpox);
- with intolerance to the components of the drug;
- with keratitis caused by Herpes sіmplex (the causative agent of herpes simplex);
- with mycobacterial eye infection;
- with a fungal infection of the eyes.
It is not used in pediatric practice.
Application during pregnancy and lactation
Method of administration and dosage
Maxitrol is intended for topical application (instillation into the eyes).
The number of instillations (instillations) is gradually reduced as the patient’s condition improves.
In milder forms of eye diseases, 1–2 drops are instilled into the conjunctival sac of the diseased eye 4–6 times / day. In severe forms, it is possible to use the medicine every hour (no more than 2 days). The standard course is 6-10 days.
Overdose symptoms of the drug: erythema, punctate keratitis, increased tearing, itching and swelling of the eyelids. Long-term and intensive use can cause systemic damage.
In case of overdose, the eye should be rinsed with clean warm water to remove excess medication. Supportive, symptomatic therapy is carried out if necessary.
- Ophthalmic disorders: keratitis, blurred vision, increased intraocular pressure, photophobia, eye pain, mydriasis, ptosis of the eyelids, swelling of the eyelids, discomfort in the eyes, itching, a feeling of a foreign body in the eyes, dry eye syndrome, eye irritation, increased tearing, hyperemia ( redness) of the eyes, the formation of crusts on the edges of the eyelids, corneal erosion, thinning of the cornea, decreased visual acuity, visual field impairment, damage to the optic nerve, the formation of posterior subcapsular cataract.
- Allergic manifestations: contact dermatitis (swelling, redness, itching, rash, irritation), angioedema, anaphylactic shock.
- Others: headache, dysgeusia (taste disturbances), dizziness,
Storage conditions and periods
Store Maxitrol drops in its original packaging (tightly closed) for no more than 2 years. Temperature conditions: 15-30 ° С. After the first use, the drops are allowed to be stored for no more than 4 weeks.