Treatment of steroid-sensitive non-infectious inflammatory and allergic conditions of the conjunctiva, cornea, and anterior segment of the eye, including inflammatory reactions in the postoperative period.
active substance: dexamethasone;
1 ml of suspension contains dexamethasone 1 mg;
excipients: polysorbate 80; hypromellose; disodium phosphate, dodecahydrate; citric acid, monohydrate; benzalkonium chloride; sodium chloride; disodium edetate; purified water.
Eye drops, suspension.
A topical drug Medexol, effectively used in ophthalmology, which contains dexamethasone as an active ingredient.
Dexamethasone is a monofluorinated synthetic glucocorticoid (adrenal cortex hormone), has anti-inflammatory, anti-allergic, antipruritic properties.
Corticosteroids produce anti-inflammatory effects by inhibiting the adhesion of molecules to vascular endothelial cells, cyclooxygenase and the release of cytokines. As a result, the formation of inflammatory mediators decreases and the adhesion of leukocytes to the vascular endothelium is inhibited, preventing their penetration into the inflamed eye tissues.
Does not have a mineralocorticoid effect.
Medexol is used in ophthalmology to treat steroid-sensitive non-infectious inflammatory and allergic diseases of the conjunctiva, cornea and anterior segment of the eye.
It is also effective against eye inflammation reactions that occur in the postoperative period.
Dexamethasone, an inhibitor of one of the phospholipase enzymes, is capable of inhibiting the synthesis of arachidonic acid.
It also has the ability to prevent the migration of leukocytes, phagocytes, the formation of kinins, the production of antitoxins, and reduce the permeability of blood vessels.
It is not used if there is an increased risk of allergy in the patient to one of the components of this medicinal product.
Contraindicated if the patient has:
- acute untreated bacterial, fungal infections;
- corneal injury or ulcer;
- mycobacterial eye infections;
- keratitis caused by herpes.
Wearing contact lenses is not recommended during treatment with this drug.
Application simultaneously with non-steroidal anti-inflammatory drugs can lead to inhibition of corneal wound healing.
It is not used in pediatrics.
Application during pregnancy and lactation
The use of this drug is contraindicated both during pregnancy and during lactation.
Method of administration and dosage
Usually, in case of severe and moderate inflammation at the initial stage of therapy, 1-2 drops of Medexol are instilled every half hour or hour. Instillation is performed in the conjunctival sac of each eye. Shake the bottle vigorously before use.
After control of the symptoms of the disease is achieved, it is permissible to reduce the dosage before using every 2-4 hours.
Then it is possible to switch to using the drug 3-4 times during the day. The same dosage is used in the treatment of allergic conjunctivitis or mild disease.
In chronic diseases, the dosage is 1-2 drops every 3-6 hours.
If the desired effect is not achieved after 3-4 days, the appointment of additional systemic or conjunctival therapy is acceptable.
The duration of treatment usually does not exceed 2 weeks. If after the first two days of therapy there is no noticeable improvement, you should change the treatment.
Regular monitoring of intraocular pressure is recommended.
Overdosage has not been observed or described to date.
In case of accidental ingestion, it is necessary to rinse the stomach, take sorbents. If you get an excess of the drug in your eyes, you should wash your eyes with clean water.
Using this drug may cause a hypersensitivity reaction, the symptoms of which are:
- erythema of the conjunctiva.
Also, the use of this medication can lead to an increase in pressure inside the eye, the development of glaucoma. In addition, it may develop:
- eye discomfort;
- irritation, redness of the eyes;
- increased intraocular pressure;
- decreased visual acuity;
- ptosis of the eyelids;
- mydriasis, pain in the eyes.
Long-term topical use of this drug may in some cases lead to the development of thinning of the cornea, the risk of its perforation.
Storage conditions and periods
Stored for up to 3 years at a temperature not exceeding 25 ° C. After opening the bottle, the properties of the drug are preserved for 4 weeks.