It is a topical antiviral. The drug is highly active against Herpes simplex viruses of the first or second type.
active substance: acyclovir;
1 tablet contains acyclovir equivalent to acyclovir anhydrous 400 mg;
excipients: anhydrous lactose, microcrystalline cellulose, croscarmellose sodium, magnesium stearate; erythrosine (E 127).
Acyclovir is a synthetic analogue of a purine nucleoside with in vivo and in vitro inhibitory activity against human herpes virus, which includes herpes simplex virus type I and II, chickenpox and shingles virus, Epstein-Barr virus and cytomegalovirus. In cell culture, acyclovir shows the greatest activity against herpes simplex virus type I and further, with decreasing activity, against herpes simplex virus type II, chickenpox and shingles virus, Epstein-Barr virus and cytomegalovirus.
- Treatment of viral infections of the skin and mucous membranes caused by herpes simplex virus, including primary and recurrent genital herpes.
- Suppression (recurrence prevention) of infections caused by the herpes simplex virus in patients with normal immunity.
- Prevention of infections caused by herpes simplex virus in patients with immunodeficiency.
- Treatment of infections caused by Varicella zoster virus (chickenpox and shingles).
Hypersensitivity to acyclovir, valacyclovir or to other components of the drug.
Medovir tablets can be used in children over 2 years of age.
Use during pregnancy or breastfeeding
Medovir tablets should be used when the potential benefit to the mother outweighs the potential risk to the fetus.
Method of application and dosage
The tablets should be taken whole with water. To achieve the required dosage, tablets with the appropriate content of active substance are used. Adequate hydration should be maintained with high doses of acyclovir.
- Treatment of infections caused by the herpes simplex virus
For the treatment of infections caused by the herpes simplex virus, it is necessary to take acyclovir at a dose of 200 mg 5 times a day with an interval of approximately 4 hours, except at night.
Treatment should last 5 days, but in case of severe primary infection it can be extended.
In patients with severe immunodeficiency (eg after bone marrow transplantation) or in patients with reduced intestinal absorption of acyclovir, the dose may be doubled to 400 mg or the appropriate dose may be administered intravenously.
Treatment should be started as early as possible after the onset of infection. In the case of recurrent herpes, it is best to start treatment in the prodromal period or after the first signs of skin lesions.
- Prevention of recurrence (suppressive therapy) of infections caused by herpes simplex virus
In patients with normal immunity, acyclovir 200 mg should be taken 4 times daily at approximately 6-hour intervals to prevent recurrence of herpes simplex virus infections.
For convenience, most patients can take Medovir 400 mg twice daily at 12-hour intervals.
Treatment will be effective even after reducing the dose of acyclovir tablets to 200 mg, which should be taken by patients 3 times a day with an 8-hour interval or even 2 times a day with a 12-hour interval.
In some patients, significant improvement is observed after taking a daily dose of acyclovir 800 mg.
To monitor possible changes in the natural course of the disease, Medovir therapy should be interrupted periodically at intervals of 6-12 months.
- Prevention of infections caused by the herpes simplex virus
To prevent infections caused by the herpes simplex virus, patients with immunodeficiency should take 200 mg acyclovir tablets 4 times a day at 6-hour intervals. For patients with severe immunodeficiency (eg, after bone marrow transplantation) or in patients with reduced intestinal absorption, the dose may be doubled to 400 mg or the appropriate dose for intravenous administration.
The duration of prevention depends on the length of the risk period.
- Treatment of chickenpox and shingles
For the treatment of infections caused by chickenpox and shingles, Medovir tablets should be taken at a dose of 800 mg 5 times a day at 4-hour intervals, except at night. The treatment should last 7 days.
In patients with severe immunodeficiency (eg, after bone marrow transplantation) or in patients with reduced intestinal absorption, it is better to use intravenous administration.
Treatment should be started as early as possible after the onset of the disease, the result will be better if treatment is started immediately after the appearance of the rash.
- For the treatment and prevention of infections caused by the herpes simplex virus, children from 2 years of age with immunodeficiency can use doses as adults.
- For the treatment of chickenpox in children aged 6 years should be prescribed 800 mg of Medovir 4 times a day, children aged 2 to 6 years can be prescribed 400 mg of Medovir 4 times a day. The duration of treatment is 5 days.
More precisely, the dose of the drug is calculated by the child’s body weight – 20 mg / kg of body weight per day (not to exceed 800 mg) Medovir, divided into 4 doses.
There are no specific data from the use of Medovir for the prevention (recurrence prevention) of infections caused by the herpes simplex virus or for the treatment of infections caused by the shingles virus in children with normal immunity.
Do not use this dosage form for children under 2 years of age.
Symptoms. Acyclovir is only partially absorbed from the gastrointestinal tract. There are reports of accidental ingestion of up to 20 g of acyclovir without toxic effects. Accidental re-overdose of oral acyclovir for several days results in gastrointestinal (such as nausea and vomiting) and neurological symptoms (headache and confusion).
In case of overdose of intravenous acyclovir, renal failure occurs, which is manifested by an increase in serum creatinine, blood urea nitrogen. Neurological manifestations of overdose may include confusion, hallucinations, agitation, convulsions and coma.
Treatment. The patient should be carefully examined for symptoms of intoxication. Because acyclovir is well eliminated from the blood by hemodialysis, the latter should be used in case of overdose.
- Mental disorders and disorders of the nervous system: headache, dizziness.
- From the gastrointestinal system: nausea, vomiting, diarrhea, abdominal pain.
- From the skin and subcutaneous tissues: itching, rash (including photosensitivity); urticaria, accelerated diffuse hair loss.
- General disorders: fatigue, fever.
Store at a temperature not exceeding 25 ° C in the original package out of reach of children.