Metformin is used to control blood sugar levels in type II diabetes. It can also be used in children from 10 years of age, including those with excess body weight, if diet therapy and physical activity are ineffective. It can be used in combination with insulin, subject to regular monitoring of blood sugar levels, in order to avoid an attack of hypoglycemia.
Metformin composition active substance: metformin hydrochloride;
1 tablet contains metformin hydrochloride 1000 mg;
Excipients: povidone K-30, colloidal anhydrous silica, magnesium stearate, opadray Y-1-7000 white (hypromellose, titanium dioxide (E 171), macrogol).
This drug Metformin belongs to a group of drugs that affect digestion and metabolic processes in the body, antidiabetic agents.
The main active ingredient is metformin. It belongs to the group of biguanides that lower blood sugar levels in non-insulin dependent type II diabetes. Reliably reduces mortality in this disease.
It is also used for polycystic ovary disease, obesity.
The mechanism of action is the ability to inhibit the synthesis of glucose by liver cells by one third. It is also able to increase the amount of cytosolic adenosine monophosphate.
Inhibits the respiratory complex I. By suppressing gluconeogenesis in the liver, increases the susceptibility of body cells to insulin, increases lipid oxidation, reducing the absorption of glucose from the gastrointestinal tract.
It increases blood circulation in the liver cells, promoting the conversion of glucose into glycogen. Decreased appetite from metformin supplementation promotes low-carb diet therapy.
Metformin is used to control blood sugar levels in type II diabetes.
It can also be used in children from 10 years of age, including those with excess body weight, if diet therapy and physical activity are ineffective.
It can be used in combination with insulin, subject to regular monitoring of blood sugar levels, in order to avoid an attack of hypoglycemia.
The drug in question is contraindicated for use in cases where the patient has severe hypersensitivity (allergy) to the main or one of the auxiliary components.
Also contraindicated for:
- eating less than 1,000 kilocalories per day;
- type I diabetes mellitus (insulin dependent);
- will have no effect on completely stopping insulin production in type II diabetes;
- symptoms of diabetic ketoacidosis, diabetic precoma, coma;
- myocardial infarction, heart failure;
- severe infections, impaired liver and kidney function;
- lung diseases, operations and injuries;
- catabolic diseases, the presence of tumors of various etiologies;
It should be borne in mind that metformin reduces its effectiveness when taking thyroid hormones, using oral contraception, diuretics, glucocorticoids.
In pediatrics, it has been used since 10 years.
Application during pregnancy and lactation
This drug is not used for the treatment of women and during lactation.
Method of administration and dosage
Metformin is taken 1 or 2 tablets a day, morning and evening, with meals, to avoid gastrointestinal side effects.
Start with taking the minimum dosage, increasing as needed.
If you need to increase the dosage, you should not increase the dose by more than 1 tablet per week, in order to avoid an unwanted bowel reaction.
The maximum daily dose is 3 grams of metformin per day.
The dosage adjustment and the duration of treatment are determined by the attending physician individually, depending on the individual indicators of the course of the disease.
The patient should consult a doctor if there are adverse reactions not specified in the instructions for medical use of the medicinal product.
An overdose can cause an attack of hypoglycemia, which can result in a coma (a sharp drop in blood glucose levels to a critical level). Symptoms of hypoglycemia: tachycardia, trembling in the limbs, increased sweating, blurred consciousness. In this case, immediately give the patient a sugar solution, in case the patient has lost consciousness, inject a glucose solution intravenously. After regaining consciousness, feed the patient with food with a high glycemic index.
It is also possible to develop lactic acidosis, the symptoms of which are nausea, vomiting, weakness, rapid breathing, muscle pain, loss of consciousness.
The development of hypoglycemia and lactic acidosis increases with the simultaneous intake of alcohol.
In some cases, side effects such as:
- dyspeptic disorders (nausea, vomiting, diarrhea);
- allergic reactions, rash, itching, allergic urticaria;
- dysgeusia, taste disturbances;
- loss or decrease in appetite;
- hepatitis, liver dysfunction (disappear after drug withdrawal).
Storage conditions and periods
Expiration date – 5 years from the date of manufacture indicated on the package.
The storage temperature should not exceed 25 ° C.