Mexia 10 is used for Alzheimer’s dementia of varying severity. Contraindications: with intolerance to the active or auxiliary components; with severe renal dysfunction.
Mexia 10 composition
active substance: memantine;
1 film-coated tablet contains memantine hydrochloride 10 mg;
excipients: microcrystalline cellulose, DC lactose (contains lactose monohydrate, povidone); colloidal anhydrous silica, talc, magnesium stearate, coating Opadry Y-1 7000 White (contains hypromellose, titanium dioxide (E 171), polyethylene glycol).
This remedy is used for dementia (acquired dementia). It is a potential-dependent noncompetitive antagonist of NMDA receptors. Blocks the effects of pathologically elevated (causing nerve cell dysfunction) glutamate levels.
Mexia 10 is used for Alzheimer’s dementia of varying severity.
- with intolerance to the active or auxiliary components;
- with severe renal dysfunction.
It is not used in pediatric practice.
Application during pregnancy and lactation
Mexia 10 is contraindicated during these periods.
Method of administration and dosage
Mexia 10 tablets are indicated for oral administration.
Therapy is allowed only if there is a guardian who regularly monitors the patient’s medication.
The dosage regimen depends on the clinical picture. Treatment is started and then carried out under the supervision of a doctor.
The tablets are taken once a day at the same time every day. Mexia 10 Tablets are taken with or without food.
The standard maintenance dose is 20 mg / day, with a maximum of 20 mg / day. In order to reduce the risk of developing typical side effects, the maintenance dose is established by gradually increasing the dose (by 5 mg per week) during the first 3 weeks:
- the first week – 5 mg / day (0.5 tablets);
- second week –10 mg / day (1 tablet);
- third week – 15 mg / day (1.5 tablets);
- starting from the fourth week – 20 mg / day (2 tablets) every day.
Intoxication symptoms: fatigue, confusion, diarrhea, weakness, agitation, aggressiveness, drowsiness, vertigo, hallucinations, vomiting, gait disturbance, diplopia, coma. It should be borne in mind that an overdose may not manifest clinically.
Symptomatic treatment is carried out, plasmapheresis is possible. If necessary, standard procedures are carried out to remove the drug from the body (gastric lavage, prescription of sorbents, forced diuresis).
- Immune disorders: allergies of varying severity, manifested by hyperemia (redness), itching, urticaria (urticaria), skin irritation, shortness of breath, allergic rhinitis (runny nose). Also, severe reactions are not excluded in the form of Quincke’s edema (rapidly developing swelling of the eyes, lips, face or part of it, larynx – with respiratory failure), anaphylactic shock (manifested by vomiting, severe itching of the skin, a drop in blood pressure, tachycardia, laryngeal edema, difficulty breathing , pallor or cyanosis of the skin, difficulty breathing, impaired consciousness).
- Mental disorders: hallucinations, confusion, drowsiness, psychotic reactions.
- Neurological disorders: gait and / or balance disorder, headache, seizures, dizziness.
- Cardiovascular disorders: venous thrombosis, thromboembolism, heart failure, arterial hypertension.
- Digestive disorders: pancreatitis, nausea, constipation.
- Respiratory disorders: shortness of breath.
- Hepatobiliary disorders: liver dysfunction, jaundice, hepatitis, increased levels of ALT / ASAT, bilirubin, alkaline phosphatase.
- Infections: fungal infections.
- General disorders: weakness, fatigue.
Storage conditions and periods
Store Mexia 10 in undamaged original packaging for no more than 3 years. Temperature conditions: 15-25 ° C.