Micardis Plus (telmisartan) tablets 80 mg/12.5 mg. №28


Micardis Plus is indicated for the treatment of arterial hypertension (persistent high blood pressure).



Micardis Plus composition
active substances: telmisartan, hydrochlorothiazide;
1 tablet contains telmisartan 80 mg and hydrochlorothiazide 12.5 mg;
excipients: povidone (E 1201); meglumine; sodium hydroxide; sorbitol (E 420); magnesium stearate (E 470b); microcrystalline cellulose; iron oxide red (E 172); sodium starch glycolate; lactose monohydrate; corn starch.

Dosage form

Pharmacological properties                                                                                                                                   Micardis Plus belongs to the group of antihypertensive drugs.
It is an angiotensin II receptor, to a combination that includes telmisartan as an antagonist and hydrochlorothiazide as a thiazide diuretic (diuretic drug).
When taken together, the antihypertensive effect of these drugs is more pronounced, blood pressure decreases more actively than if they are used separately. With a single daily intake for a long time, blood pressure is stable, although gradually, decreases.
Telmisartan has the property of causing a decrease in the concentration of the steroid hormone aldosterone in the blood, while it does not inhibit the proteolytic enzyme renin in the blood plasma, does not cause blocking of ion channels.
Also, telmisartan does not affect the inhibition of the angiotensin-converting enzyme kininase-II. The latter does not cause the destruction of bradykinins and, along with them, the appearance of side effects usually caused by bradykinin.
After taking the drug, it causes a noticeable effect after 3 hours, then it produces an effect for another 24 hours, and within 48 – the effect is still significant for the human body. A persistent decrease in blood pressure develops after 4 weeks of continuous administration of the drug.
In this case, the heart rate does not depend on the influence of telmisartan.
If the drug is abruptly canceled, “withdrawal syndrome” will not occur.
Studies have shown that regular use of this drug leads to a proven decrease in the number of cardiovascular diseases in patients with blood vessel diseases, diabetes mellitus, and other systemic diseases that can accompany and potentiate arterial hypertension.

Micardis Plus is indicated for the treatment of arterial hypertension (persistent high blood pressure).

The drug in question is not used if the patient has ever had hypersensitivity (allergy) to one of the components that make up its composition.
Do not use if the patient suffers from:

  • obstructive diseases of the biliary tract;
  • severe impairment of liver and / or kidney function;
  • refractory hypokalemia, hypercalcemia.

Caution should be exercised when treating patients who have:

  • diarrhea, vomiting, hypercholesterolemia, hypertriglyceridemia;
  • condition after kidney transplantation;
  • chronic heart failure, ischemic heart disease, mitral stenosis, cardiomyopathy;
  • diabetes mellitus, gout, hyperuricemia, systemic lupus erythematosus;
  • glaucoma.

Application during pregnancy and lactation
This drug is contraindicated for the treatment of pregnant women.
Lactation is suspended for the duration of treatment with this drug.

Method of administration and dosage
Recommended dosage regimen of Micardis Plus: 1 tablet once a day.
A dosage of 40 or 80 mg of telmisartan is chosen by the attending physician, depending on the nature of the course of the disease.
The exact duration of the therapeutic course is determined by the attending physician.
In severe arterial hypertension, the maximum dosage based on the amount of telmisartan is not more than 160 mg per day.
With moderate impairment of the kidneys or liver, the dose of telmisartan should not exceed 40 mg per day.
Elderly patients do not need dosage adjustment.

Overdoses with this drug are extremely rare.
Possible increased side effects in the form of:

  • drop in blood pressure;
  • violations of water and electrolyte balance;
  • bradycardia;
  • drowsiness, nausea.

In case of accidental overdose, symptomatic treatment should be applied. Reception of enterosorbents can improve the patient’s condition.

Side effects
The use of this drug in a patient can cause side effects in the form of:

  • infections of the upper respiratory tract, urinary tract (cystitis, bronchitis, pharyngitis, sinusitis, sepsis);
  • inflammation of the salivary glands;
  • anemia, thrombocytopenia, leukopenia, neutropenia, agranulocytosis;
  • symptoms of systemic lupus erythematosus, manifestations of allergies;
  • violations of glucose tolerance;
  • hypokalemia, hyperkalemia, hyponatremia, hyperuricemia, hypoglycemia;
  • decreased appetite, pancreatitis, nausea, jaundice, anxiety, depression;
  • dizziness, paresthesia, insomnia;
  • hearing and vision impairments;
  • arrhythmias, tachycardia, bradycardia;
  • orthostatic hypotension, shortness of breath, impaired renal or liver function;
  • myalgia, arthralgia, back pain, muscle spasms.

Storage conditions and periods
This medicinal product retains its medicinal properties for 3 years, which are counted from the production date specified by the manufacturer.
The drug should be kept out of the reach of children. Storage temperature should not exceed 25 ° C.