Motorix (domperidone) coated tablets 0.01 g. №10


Motorix is ​​used to relieve symptoms of nausea and vomiting, a feeling of full stomach, upper abdominal pain, heartburn, whether or not stomach contents are ejected into the mouth.
In childhood, it is used to relieve symptoms of nausea and vomiting.



Motorix composition
The main active ingredient of the drug is domperidone maleate. The list of auxiliary components includes: corn starch, magnesium stearate, microcrystalline cellulose, anhydrous colloidal silicon dioxide, sodium lauryl sulfate.

Release form
It is produced in the form of tablets, in a dosage of 10 mg of domperidone in one tablet.

Pharmacological properties
Motorix belongs to a group of drugs designed to stimulate intestinal motility, based on domperidone.
Domperidone is a dopamine antagonist that has antiemetic properties.
The antiemetic properties of this drug are due to the fact that peripheral (gastrokinetic) action is harmoniously combined in it, as well as antagonism relative to dopamine receptors, in the trigger zone of chemoreceptors, which are outside the blood-brain barrier in the posterior region.
It is known that when used internally, domperidone is able to increase the duration of antral and duodenal contractions, and accelerates bowel movement.
In this case, domperidone has no effect on gastric secretion.

Motorix is ​​used to relieve symptoms of nausea and vomiting, a feeling of full stomach, upper abdominal pain, heartburn, whether or not stomach contents are ejected into the mouth.
In childhood, it is used to relieve symptoms of nausea and vomiting.
The mechanism of action is due to the chemical and physical properties of the main active ingredient – domperidone.
This substance is able to penetrate in some amount through the blood-brain barrier.
The use of this drug in rare cases is accompanied by extrapyramidal side effects, especially in adults, but domperidone can also stimulate the release of prolactin from the pituitary gland.
There is also officially recorded evidence that low concentrations that were detected in the brain indicate a predominantly peripheral effect of domperidone on dopamine receptors.

Not applicable if the patient has hypersensitivity (allergy) to one of the components that make up the drug.
Also use is contraindicated in the case of:

  • prolactin-secretory tumor of the pituitary gland (prolactinoma);
  • liver and / or kidney or liver dysfunctions;
  • liver failure;
  • in patients who have recorded prolongation of the QT interval, which are the cause of cardiac dysfunction;
  • phenylketonuria.

Do not use if vomiting occurs when:

  • gastrointestinal bleeding;
  • mechanical obstruction;
  • perforation;
  • motion sickness.

It is not used simultaneously with drugs that prolong the QT interval, erythromycin, fluconazole, ketoconazole, itraconazole, posaconazole, ritonavir, saquinavir, telaprevir, voriconazole, clarithromycin, amiodarone, telithromycin.

In pediatrics, they are used from the moment they reach the age of 12, in children weighing 35 and over kilograms.

Application during pregnancy and lactation
This drug has not been tested in pregnant women, so it is not known what effect it has on the fetus and the woman’s health during this period.
As a consequence, its use during pregnancy can only be used if the risk from use is lower than its health benefits.
If there is a need to use this drug during lactation, then breastfeeding should be suspended.

Method of administration and dosage
To relieve the symptoms of chronic dyspepsia – nausea and vomiting – Motorix is ​​used 1 tablet up to 3 times a day. For greater effect, it is taken before meals (15-30 minutes), and before bedtime, if necessary.
If necessary, the dose can be doubled by taking 2 tablets three times a day (with severe vomiting and nausea).
The maximum dose that can be taken per day is 80 mg.
The duration of the primary treatment is 4 weeks. The extension of treatment is determined by the attending physician.
If the patient is diagnosed with renal failure, the frequency of taking the drug should be reduced.

An overdose of this drug can be characterized by symptoms such as:

  • agitation;
  • disturbances of consciousness, convulsions;
  • disorientation, drowsiness;
  • extrapyramidal reactions.

A specific antidote has not yet been identified.
Recommended gastric lavage within the first hour after poisoning, intake of enterosorbents, symptomatic treatment.
Anticholinergic drugs can be effective in controlling extrapyramidal reactions.

Side effects
When using this drug, side effects have been observed such as:

  • allergies, up to anaphylactic shock;
  • increased prolactin levels;
  • nervousness, dizziness, thirst, depression, convulsions, fatigue, headache, drowsiness, extrapyramidal disorders;
  • edema, tachycardia, ventricular arrhythmia, sudden cardiac death;
  • dry mouth, short-term intestinal cramps, diarrhea, nausea, heartburn, constipation;
  • itching, rash, urticaria, angioedema;
  • enlargement, pain, swelling of the mammary glands, gynecomastia, amenorrhea, lactation disorders, irregular menstrual cycle;
  • dysuria, frequent urination, asthenia;
  • conjunctivitis, stomatitis.

If you have any unusual side effects as a result of taking this drug, you should consult your doctor about possible changes in the treatment regimen.

Storage conditions and periods
Stored Motorix for up to 3 years at a temperature not exceeding 30 ° C.