Mutaflor (escherichia coli) capsules №20


Chronic constipation.
Nonspecific ulcerative colitis in remission.



Mutaflor composition
active substance: Escherichia coli strain NISSLE 1917;
composition per 1 unit of dosage form:
Escherichia coli strain NISSLE 1917 – 2.5 – 25×109 live bacterial cells (colony-forming units, CFU);
Excipients: maltodextrin, talc, copolymer (1: 1) of methacrylic acid – methyl methacrylate, macrogol (4000), triethyl citrate, glycerin 85%, titanium dioxide (E 171), iron oxide red (E 172), gelatin, yellow wax, wax carnauba, shellac, purified water.

Dosage form
Capsules are gastroresistant, hard.

Pharmacological properties
The active substance is a strain of non-pathogenic bacteria of human origin, belonging to the species Escherichia coli (E. coli), in a living and reproducible form: E. coli strain NISSLE 1917. Using special adhesive organelles (type F-1A, F- 1C and “curly” fimbriae) the strain has the ability to attach to the mucous membrane of the colon and form microcolonies in the form of a biofilm. Due to the presence of flagella, bacteria are characterized by mobility, which gives them an advantage when colonizing the large intestine. The effects of Mutaflor (E. coli strain NISSLE 1917) were determined in in vitro and in vivo experiments, as well as in clinical trials.

Chronic constipation.
Nonspecific ulcerative colitis in remission.

Hypersensitivity to the ingredients of the drug.

Use for children over 15 years.

Method of application and dosage
The entire daily dose should be taken with food, preferably at breakfast, drinking plenty of fluids. Do not chew the capsules.
If bloating develops or if an initial dose greater than the standard recommended is taken, the daily dose may be divided between all daily meals.
Adults and adolescents.
Standard dose: from the first to the fourth day of reception – 1 capsule of the drug Mutaflor per day, then – 2 capsules of the drug Mutaflor per day.
In case of prolonged constipation, the dose can be increased to 4 capsules of Mutaflor daily.
With ulcerative colitis. The experience of using the drug for 12 months in ulcerative colitis is based on the results of controlled studies. To prevent recurrence of ulcerative colitis, Mutaflor should be taken continuously.
With chronic constipation. Mutaflor can be taken for 6 weeks. If the disease persists for many years, Mutaflor can be considered as a tonic, and therefore therapy with its use should be repeated periodically.

There are no data on drug overdose.

Side effects
The drug is well tolerated. In rare cases, the following symptoms may occur:

  • From the gastrointestinal tract: at the beginning of therapy, bloating is common.
  • From the skin: rash, erythema and peeling of the skin, allergic reactions.
  • From the central nervous system: there are isolated reports of headaches.

Expiration date
12 months.

Storage conditions
Store at a temperature of 2 – 8 oC in places inaccessible to children.
Do not use after the expiry date stated on the package.