Nebilet Plus coated tablets 5 mg/12.5 mg. №28


Nebilet Plus is prescribed for arterial hypertension.



Nebilet Plus composition and form of release
Active ingredient: nebivolol hydrochloride (5 mg), hydrochlorothiazide (12.5 mg).
Available in tablet form.

Pharmacological properties
This is a combination medicine used for heart disease. Is a selective (selective) blocker of beta-adrenergic receptors. The drug has a membrane stabilizing effect, has an internal sympathomimetic activity. Nebivolol reduces the activity of renin, reduces the heart rate during exercise and at rest, and reduces the oxygen demand of the heart muscle. It also has antianginal, antiarrhythmic, antihypertensive effects. By blocking beta1-adrenergic receptors of the heart, it reduces the formation of cAMP from adenosine triphosphate, reduces the current of calcium ions inside cells, has a negative chronotropic, dromotropic, batmotropic, inotropic effect. Hydrochlorothiazide is a diuretic.

Nebilet Plus is prescribed for arterial hypertension.


  • if you are allergic to nebivolol hydrochloride, other beta-blockers;
  • with intolerance to the auxiliary components of the drug;
  • with AV blockade II – III st. (without using an artificial pacemaker);
  • in case of shock (including cardiogenic shock);
  • with sinoatrial blockade;
  • with chronic insufficiency of heart function in the stage of decompensation;
  • with acute heart failure;
  • with insufficient liver function;
  • with cardiomegaly without signs of failure;
  • with sick sinus syndrome;
  • with severe bradycardia;
  • with chronic obstructive pulmonary disease;
  • with arterial hypotension;
  • with bronchial asthma;
  • in the later stages of peripheral circulatory disorders (for example, Raynaud’s disease);
  • while taking certain medications (see the package insert);
  • with anuria;
  • with severe peripheral circulatory disorders;
  • with pheochromocytoma;
  • with hypokalemia, hyponatremia, hypercalcemia, symptomatic hyperuricemia;
  • with metabolic acidosis.

It is not used in pediatrics.

Application during pregnancy and lactation
The use of Nebilet Plus in pregnant women is allowed only under strict indications. Possible negative effects on the fetus (growth retardation, bradycardia, hypoglycemia).
Contraindicated during lactation.

Method of administration and dosage
The tablet is taken orally in the morning on an empty stomach with a little water.
The recommended dose is one tablet once a day.

Symptoms: arrhythmia, incl. ventricular premature beats, AV block, severe bradycardia, drop in blood pressure, acute heart failure, acrocyanosis (cyanosis of the extremities), fainting, bronchospasm, shortness of breath, convulsions, dizziness, electrolyte imbalance.
Overdose treatment: discontinuation of intake, gastric lavage, prescription of sorbents, symptomatic therapy.

Side effects:

  • Metabolic disorders: anorexia, diabetes mellitus, dehydration, gout, metabolic alkalosis, hyperuricemia, electrolyte imbalance, hyperglycemia, hyperamilasemia.
  • Immune disorders: angioedema, allergic reactions.
  • Neurological disorders: headache, increased fatigue, dizziness, paresthesia, nightmares, depression, syncope.
  • Ophthalmic disorders: dry eyes.
  • Changes in the blood test: leukopenia, neutropenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia.
  • Cardiovascular disorders: peripheral edema, bradycardia, heart failure, orthostatic hypotension, delayed atrioventricular conduction (including AV block), exacerbation of intermittent claudication.
  • Respiratory disorders: shortness of breath, bronchospasm.
  • Digestive disorders: nausea, constipation / diarrhea, flatulence, vomiting.
  • Dermatological disorders: itching of the skin, erythematous rash, exacerbation of the course of psoriasis, urticaria.
  • Genitourinary disorders: erectile dysfunction.
  • Mental disorders: hallucinations, confusion, psychosis, Raynaud’s phenomenon, coldness / cyanosis of the extremities.

Storage conditions and periods
Store Nebilet Plus at room temperature for no more than three years.