Neurobex NEO (B vitamins) capsules №60


Manufacturer: Indonesia



Neurobex NEO composition
active substances: thiamine nitrate (vitamin B1), riboflavin sodium phosphate, in terms of riboflavin (vitamin B2), pyridoxine hydrochloride (vitamin B6), cyanocobalamin (vitamin B12), nicotinamide (vitamin B3), calcium panto acid (vitamin B9), ascorbic acid (vitamin C);
Excipients: colloidal anhydrous silica, talc, magnesium stearate, potato starch, calcium hydrogen phosphate.

Dosage form

Pharmacological properties
Neurobex NEO is combination of B vitamins, which is part of the drug Neurobex Neo, affects a number of processes occurring in the body. Vitamins of this group are part of enzymes that catalyze the metabolism of carbohydrates, lipids and proteins. The combination of B vitamins in Neurobex Neo helps to normalize the metabolism of autonomic centers, the processes of formation, impulse transmission and trophism of neurons, improves the functioning of nerve cells and subcortical centers, thereby normalizing the vegetative-emotional status.

  • Vitamin B1 (thiamine nitrate). After resorption, it is converted in the body into thiamine pyrophosphate, which is a coenzyme of those enzymes involved in the decarboxylation of pyruvic and alpha-ketoglutaric acids.
  • Thiamine is involved in carbohydrate and energy metabolism, especially in nerve and muscle tissues, affects the conduction of nerve excitation at synapses. And also participates in fat, protein and water-salt metabolism, in the synthesis of acetylcholine.
  • Vitamin B2
  • Riboflavin plays an important role in maintaining normal eye function and hemoglobin synthesis.
  • Upon entering the body, riboflavin interacts with adenosine triphosphate and forms a flavin mononucleotide and flavin adenine nucleotide, which are coenzymes of flavin proteins and are involved in hydrogen transfer and regulation of redox processes.
  • Vitamin B5 (calcium pantothenate).
  • Participates in the production of adrenal hormones – glucocorticoids; in carbohydrate and fat metabolism, in the synthesis of acetylcholine and corticosteroids. In the body, pantothenic acid is part of coenzyme A, which plays an important role in the processes of acetylation and oxidation. Improves regeneration processes and energy supply of myocardial contractile function, enhancing the cardiotonic effect of cardiac glycosides and increasing their therapeutic efficacy.
  • Vitamin B6 (pyridoxine hydrochloride) plays an important role in metabolism. It is necessary for the normal functioning of the central and peripheral nervous system. Upon entering the body, it is phosphorylated, converted to pyridoxal-5-phosphate and is part of the enzymes that carry out decarboxylation and preamination of amino acids. Pyridoxine is involved in protein metabolism and the synthesis of neurotransmitters, in the metabolism of tryptophan, methionine, cysteine, glutamine and other amino acids. It also plays an important role in the metabolism of histamine, in the processes of fat metabolism, improves the function of the liver and nerve fibers, lipid metabolism in atherosclerosis.
  • Vitamin B9 (folic acid) in the body is reduced to tetrahydrofolic acid, which is a coenzyme involved in various metabolic processes. Folic acid is necessary for the normal formation of blood cells, including the processes of maturation of megalobasts and the formation of normoblasts. Folic acid deficiency inhibits the transition of the megaloblastic phase of hematopoiesis to normoblastic. Together with vitamin B12 stimulates erythropoiesis, participates in the synthesis of amino acids (eg, methionine, serine), nucleic acids, purines and pyrimidines, in the metabolism of choline; required for cell division.
  • Vitamin B12 (cyanocobalamin) is converted in the body by cobalamide, which is the active form of vitamin B12. Has high biological activity. Is a growth factor necessary for normal hematopoiesis and erythrocyte maturation. Participates in the synthesis of labile methyl groups and in the formation of choline, methionine, creatine, nucleic acids. Promotes the accumulation in erythrocytes of compounds containing sulfhydryl groups, which increases their tolerance to hemolysis. Activates the coagulation function of the blood system, in high doses causes an increase in thromboplastic activity and prothrombin activity. Activates the metabolism of carbohydrates and lipids. In atherosclerosis, it slightly lowers blood cholesterol levels and increases the lecithin-cholesterol index. Favorably affects the function of the liver and nervous system. Improves tissue regeneration.
  • Vitamin PP (nicotinamide) is a prosthetic group of enzymes – codehydrase (diphosphopyridine nucleotide – NAD) and codehydrase (triphosphopyridine nucleotide – NADP), which carry hydrogen and provide redox processes. Codehydrase is also involved in phosphate transfer. Vitamin PP is a specific anti-pelagic agent. Improving carbohydrate metabolism, has a positive effect on mild forms of diabetes, liver disease, heart disease, diseases of the gastrointestinal tract, with slow healing of wounds and ulcers. It also causes vasodilating effect, hypolipidemic activity: causes a decrease in total cholesterol, low-density lipoprotein and especially triglycerides; the content of high-density lipoproteins in the blood increases.
  • Vitamin C (ascorbic acid). Participates in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, the formation of steroid hormones, has well-defined restorative properties. One of the important physiological functions of ascorbic acid is its participation in the synthesis of procollagen and collagen, as well as the normalization of capillary permeability. There is evidence of a positive effect of ascorbic acid on lipid metabolism in atherosclerosis.

Hypo- and avitaminosis is caused by a lack of B vitamins. Nonspecific and degenerative diseases of peripheral nerves – neuritis, polyneuropathy (alcoholic, post-infection, toxic), neuralgia, paresthesia; encephalopathy, asthenia, myasthenia, plexitis, osteochondrosis, radicular syndromes, neurocirculatory dystonia.
Spastic conditions of central origin, traumatic injuries of the central nervous system, autonomic neuroses, chronic alcoholism, intoxication.
In combination therapy in:

  • degenerative processes in the retina, diabetic retinopathy, macular degeneration, optic neuritis, toxic lesions of the optic nerve, increased sensitivity to light;
  • auditory nerve neuritis, sensorineural deafness, toxic and drug lesions of the auditory nerve;
  • recovery period after cardiovascular disease, chronic circulatory failure, myocarditis, myocardial infarction;
  • gastritis, duodenitis, enterocolitis, pancreatitis, enteritis, liver disease (hepatitis, cirrhosis);
  • dermatological diseases: dermatitis of neurogenic origin (seborrheic and non-seborrheic), eczema, psoriasis, acne, shingles, neurodermatitis, exudative diathesis, other skin diseases, cracks and peeling of the skin in the corners of the mouth;
  • asthenic conditions: increased fatigue, chronic fatigue, depression, irritability, nervousness, sleep and appetite disorders, decreased concentration and memory impairment;
  • treatment of chronic alcoholism, courses of antibiotic therapy, smoking;
  • in conditions accompanied by an increased need for vitamins (infectious diseases, during convalescence;
    after chemical poisoning).

Allergic reactions to the components of the drug Neurobex NEO.
Acute thromboembolism, erythrocytosis and erythremia.
Folic acid should not be used in malignancies, except in cases of megaloblastic anemia, which developed as a complication of folic acid deficiency.
Ascorbic acid is contraindicated in case of hyperoxaluria.
Predisposition to thrombosis, thrombophlebitis, severe kidney disease, gastric and duodenal ulcers, severe liver dysfunction, active hepatitis, tumors, hypertension (severe forms), gout, guperuricemia, nephrolithiasis, iron and copper metabolism disorders.

Children                                                                                                                                                                                  There are no clinical data on use in children under 12 years of age.

Use during pregnancy or breastfeeding
No clinical trials have been performed in women during pregnancy, therefore the drug should be used with caution, especially in the first trimester of pregnancy, and only on prescription if the expected benefit of the drug outweighs the potential risk to the fetus / child. breastfeeding or the use of the drug should be taken taking into account the importance of taking the drug for the mother. If you need to use the drug should stop breastfeeding for this period.

Method of application and dosage
Take Neurobex NEO the capsules orally, during or after a meal, with water.
Usual dose: 1 capsule once a day for 2-4 weeks or longer (if necessary).
The dose and duration of treatment Neurobex NEO is determined by your doctor.
Recommended daily doses in complex treatment:

  • for neurological diseases and symptoms: adults and children over 12 years of age 1 capsule 2 times a day;
  • for combination therapy of various diseases: adults and children over 12 years of age 1 capsule 1-2 times a day.

In some people with glucose-6-phosphate dihydrogenase deficiency, ascorbic acid may lead to acidosis or hemolytic anemia. With a significant overdose of ascorbic acid may develop renal failure.
Ascorbic acid is a water-soluble vitamin, its excess is excreted in the urine. However, with long-term use of vitamin C in large doses may suppress the function of the insular apparatus of the pancreas, which requires monitoring of the latter. Overdose can lead to changes in renal excretion of ascorbic and uric acids during acetylation of urine with the risk of precipitation of oxalate stones.
Overdose may cause dyspepsia, allergic reactions, skin and hair changes, liver dysfunction, headache, drowsiness, lethargy, facial flushing, and irritability. In such cases, the drug should be discontinued.
Gastric lavage and, if necessary, other supportive care should be performed. Excess vitamin B is easily eliminated from the body, so after the introduction of vitamin B in this dosage form, no serious problems are expected.

Side effects:

  • From the gastrointestinal tract: rarely – anorexia, nausea, bloating / flatulence; frequency unknown – vomiting, stomach cramps, diarrhea.
  • On the part of the immune system: rarely – allergic reactions, including erythema, rash, itching, urticaria, dyspnea and anaphylactic reactions (including shock), anaphylaxis, fever.
  • From the vessels: the frequency is unknown – hot flashes.
  • From the skin and subcutaneous tissue: rarely – urticaria, exanthema, eczematous rash. Allergic reactions include skin manifestations and Quincke’s edema; frequency unknown – redness.
  • From the nervous system: frequency unknown – headache.
  • From the kidneys and urinary system: frequency unknown – a slight increase in urination.
  • It is known that the use of individual components of the drug has been reported to develop the following adverse reactions:
  • From the respiratory system: bronchospasm.
  • From the cardiovascular system: hypertension, myocardial dystrophy.
  • From the blood: hemolysis of erythrocytes in patients with glucose-6-phosphate dehydrogenase deficiency, coagulation disorders.
  • From the nervous system: dizziness, sleep disturbances, irritability, fatigue.
  • From the gastrointestinal tract: dyspepsia, heartburn, belching, stomach pain, increased secretion of the gastric eye, damage to the insular apparatus of pancreatic acid and impaired glycogen synthesis until diabetes mellitus, damage to the glomerular apparatus of the kidneys, the formation of kidney stones and kidney stones. renal failure, discoloration of urine.
  • Others: hypercalciuria, crystalluria, glucosuria, sensation of heat, metabolic disorders of zinc, copper, irritability, hyperhidrosis.

Expiration date
3 years.

Storage conditions
Store Neurobex NEO in the original package at a temperature not exceeding 25 oC.
Keep out of reach of children.