Degenerative-involutional brain psychoorganichni syndromes or secondary consequences of cerebrovascular insufficiency, that is, primary and secondary disorders of mental activity in the elderly, characterized by memory impairment, confusion, disorientation, decreased motivation and initiative, reduced ability to concentrate; changes in the emotional and behavioral sphere: emotional instability, irritability, indifference to the environment; pseudomelanholia in the elderly.
active substance: choline alfoscerate;
1 ml of the drug contains choline alfoscerate 250 mg;
Excipient: water for injections.
Solution for injection.
Neurotilin belongs to the group of central cholinomimetics with a predominant effect on the central nervous system (CNS). Choline alfoscerate as a carrier of choline and a precursor agent of phosphatidylcholine has the potential to prevent and correct biochemical damage, which are particularly important among the pathogenic factors of psychoorganic involutional syndrome, ie may affect reduced cholinergic tone and altered phospholipid cell membranes. The drug contains 40.5% of metabolically protected choline. Metabolic protection provides the release of choline in the brain. Neurothylin has a positive effect on memory function and cognition, as well as on indicators of emotional state and behavior, the deterioration of which was caused by the development of involutional brain pathology.
The mechanism of action is based on the fact that when choline enters the body, alfoscerate is broken down by enzymes into choline and glycerophosphate: choline is taught in the biosynthesis of acetylcholine – one of the main mediators of nervous excitation; glycerophosphate is a precursor of phospholipids (phosphatidylcholine) of the neuronal membrane. Thus, Neurothylin improves the transmission of nerve impulses in cholinergic neurons; has a positive effect on the plasticity of neuronal membranes and the function of receptors. Neurothylin improves cerebral blood flow, enhances metabolic processes in the brain, activates the structures of the reticular formation of the brain and restores consciousness in traumatic brain injury.
Acute period of severe traumatic brain injury with predominantly stem level of damage (disturbance of consciousness, coma, focal hemispheric symptoms, symptoms of brain stem damage).
Degenerative-involutional cerebral psychoorganic syndromes or secondary consequences of cerebrovascular insufficiency, ie primary and secondary mental disorders in the elderly, characterized by memory impairment, confusion, disorientation, decreased motivation and initiative, decreased ability to concentrate; changes in the emotional sphere and the sphere of behavior: emotional instability, irritability, indifference to the environment; pseudomelancholia in the elderly.
Known hypersensitivity to the drug or its components.
Psychotic syndrome, severe psychomotor agitation.
There is no experience of using the drug in children.
Use during pregnancy or breastfeeding
The drug is contraindicated for use during pregnancy or breastfeeding.
Method of application and dosage
In acute conditions, administer Neurotilin intramuscularly or intravenously (slowly) 1 g (1 ampoule) per day for 15 to 20 days. Then, after stabilization of the patient’s condition, switch to the dosage form of the drug in capsules.
In case of neurotylin overdose, which may be manifested by nausea, anxiety, agitation, insomnia, the dose should be reduced. Therapy is symptomatic.
As a rule, the drug is well tolerated even with prolonged use. Possible reactions at the injection site. During the first days or weeks of treatment, the following manifestations of side effects may occur: anxiety, agitation, insomnia. These symptoms are temporary and do not require discontinuation of treatment, but the dose may be temporarily reduced.
Nausea (mainly due to secondary dopaminergic activation), low blood pressure, headache, very rarely abdominal pain and short-term confusion are possible. In this case, it is necessary to reduce the dose of the drug.
Hypersensitivity reactions may occur, including rash, pruritus, urticaria, angioneurotic edema, and reddening of the skin.
Store in the original package at a temperature not exceeding 25 ° C.
Keep out of reach of children.