Stroke, acute phase of cerebrovascular accidents and their neurological consequences. Traumatic brain injury and its neurological consequences. Cognitive and behavioral disorders due to chronic vascular and degenerative cerebral disorders.
active substance: citicoline;
1 tablet contains citicoline monosodium salt (in terms of citicoline) 500 mg;
excipients: microcrystalline cellulose, croscarmellose sodium, polyethoxylated castor oil, hydrogenated with a mineral carrier magnesium aluminometasilicate, talc, hydrophobic colloidal silicon dioxide, magnesium stearate, coating mixture “Aquarius Prime BKN318029 White” titanium cellulose, which contains hydroxypropyl cellulose dioxide.
Citicoline stimulates the biosynthesis of structural phospholipids of neuronal membranes, which is confirmed by the data of magnetic resonance spectroscopy. Due to this mechanism of action, citicoline exhibits the functioning of such membrane mechanisms as the work of ion-exchange pumps and receptors, the modulation of which is necessary for the normal conduction of nerve impulses. Due to the stabilizing effect on the membrane of neurons, citicoline exhibits anti-edema properties that contribute to the reabsorption of cerebral edema.
Experimental studies have shown that citicoline inhibits the activation of certain phospholipases (A1, A2, C, and D), reducing the formation of free radicals, preventing the destruction of membrane systems, and preserving antioxidant defense systems such as glutathione.
Citicoline preserves the energy supply of neurons, inhibits apoptosis and stimulates the synthesis of acetylcholine.
It has been experimentally proven that citicoline also exhibits a preventive neuroprotective effect in focal cerebral ischemia.
Clinical studies have shown that citicoline significantly increases the indicators of functional recovery in patients with acute ischemic cerebrovascular accident, which coincides with a slowdown in the growth of ischemic brain damage according to neuroimaging data.
In patients with traumatic brain injury, citicoline accelerates recovery and reduces the duration and intensity of post-traumatic stress disorder.
Citicoline improves the level of attention and consciousness, cognitive and neurological disorders associated with cerebral ischemia, helps to reduce the manifestations of amnesia.
Indications for Neuroxon use:
- Stroke, acute phase of cerebrovascular accidents and their neurological consequences.
- Traumatic brain injury and its neurological consequences.
- Cognitive and behavioral disorders due to chronic vascular and degenerative cerebral disorders.
Hypersensitivity to citicoline or other components of the drug.
High tone of the parasympathetic nervous system.
The experience of using the drug in children is limited, therefore, the drug should be prescribed only when the expected benefit outweighs any potential risk.
Application during pregnancy or lactation
There are no sufficient data on the use of citicoline in pregnant women. Citicoline should not be used during pregnancy, unless absolutely necessary. During pregnancy, the drug should be prescribed only when the expected therapeutic benefit outweighs the potential risk. Data on the penetration of citicoline into breast milk and its effect on the fetus are unknown.
Method of administration and dosage
The recommended dose is from 500 to 2000 mg per day (1-4 tablets).
Doses of the drug and the duration of treatment depend on the severity of the brain damage and are set by the doctor.
Elderly patients do not require dose adjustment.
Overdose cases were not noted.
- From the side of the psyche: hallucinations.
- From the nervous system: severe headache, dizziness.
- From the side of the cardiovascular system: arterial hypertension, arterial hypotension, tachycardia.
- From the respiratory system: dyspnea.
- From the digestive tract: nausea, vomiting, episodic diarrhea.
- Allergic reactions, including rash, itching, angioedema, anaphylactic shock, redness, urticaria, exanthema, purpura.
- General disorders: chills, edema.
Store Neuroxon in its original packaging at a temperature not exceeding 25 ºС. Keep out of the reach of children.